Using advanced MRI to improve deep brain stimulation for Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the effectiveness of deep brain stimulation (DBS) for patients with advanced Parkinson's disease by utilizing 7-Tesla MRI technology. The study focuses on visualizing the brain networks connected to the subthalamic nucleus (STN), which is crucial for DBS treatment. By mapping these networks, the researchers hope to improve the precision of electrode placement and stimulation settings, potentially leading to better patient outcomes. The study will include individuals who have undergone STN DBS and will analyze their brain connectivity using advanced imaging techniques.

Why it matters

Who can join: the full rules

1.2 Inclusion criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:

* Age \> 18 years;
* Idiopathic PD who underwent STN DBS

1.3 Exclusion criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:

* Legally incompetent adults;
* No written informed consent.

Where it's running

• Amsterdam UMC, location AMC
  Amsterdam, North Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Maarten Bot, MD PhD — Amsterdam UMC
• Study coordinator: Maarten Bot, MD PhD
• Email: m.bot@amsterdamumc.nl
• Phone: 0031621514048

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How physical activity might help people with Parkinson’s disease who have DBS-STN implants

  This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.

  Recruiting Medical University of Warsaw · Warsaw · NCT07838636

• Patterned deep brain stimulation delivered at home for Parkinson's

  This study will test whether three types of patterned deep brain stimulation can be used safely and comfortably at home in people with Parkinson's who already have stable bilateral STN or GPi Boston Scientific DBS systems.

  Recruiting University of Florida · Gainesville, Florida · NCT07410598

• Mediterranean diet for managing weight and body composition after bilateral subthalamic nucleus deep brain stimulation in Parkinson's disease

  It will see if following a Mediterranean diet for three months after bilateral subthalamic nucleus deep brain stimulation helps adults with Parkinson's control weight and improve body composition.

  Recruiting Ankara University · Ankara, Ankara · NCT07187739

• Frequency-specific stimulation of subthalamic nucleus subregions to improve inhibitory control in Parkinson's disease

  This tests whether stimulating different parts of the subthalamic nucleus at low (5 Hz) or high (130 Hz) frequencies can improve inhibitory control in people with Parkinson's disease who have deep brain stimulation.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07022522

• How deep brain stimulation affects thinking and memory in Parkinson's

  This project will use MRI scans to see if subthalamic nucleus deep brain stimulation (DBS) changes brain networks and relates to thinking or memory declines in people with Parkinson's disease who already have DBS implants.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06960096

• Advanced brain imaging for improving deep brain stimulation in Parkinson's and essential tremor patients

  This study is testing if advanced brain imaging can help doctors place and program deep brain stimulation better for people with Parkinson's disease and essential tremor to improve their movement.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06932692

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.