Using advanced MRI to improve deep brain stimulation for Parkinson's disease
The STEREO-DBS Study: 7-Tesla MRI Brain Network Analysis for Deep Brain Stimulation
This study is testing if using advanced MRI technology can help improve deep brain stimulation for people with advanced Parkinson's disease by better targeting the brain areas that control movement.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT05843084 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enhance the effectiveness of deep brain stimulation (DBS) for patients with advanced Parkinson's disease by utilizing 7-Tesla MRI technology. The study focuses on visualizing the brain networks connected to the subthalamic nucleus (STN), which is crucial for DBS treatment. By mapping these networks, the researchers hope to improve the precision of electrode placement and stimulation settings, potentially leading to better patient outcomes. The study will include individuals who have undergone STN DBS and will analyze their brain connectivity using advanced imaging techniques.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with idiopathic Parkinson's disease who have already undergone STN DBS.
Not a fit: Patients who are legally incompetent or unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized and effective DBS treatments, improving motor symptoms and quality of life for patients with Parkinson's disease.
How similar studies have performed: While the use of advanced MRI techniques in DBS is a novel approach, previous studies have shown that targeting brain networks can lead to improved outcomes in similar contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
1.2 Inclusion criteria In order to be eligible to participate in this study, a subject must meet all of the following criteria: * Age \> 18 years; * Idiopathic PD who underwent STN DBS 1.3 Exclusion criteria A potential subject who meets any of the following criteria will be excluded from participation in this study: * Legally incompetent adults; * No written informed consent.
Where this trial is running
Amsterdam, North Holland
- Amsterdam UMC, location AMC — Amsterdam, North Holland, Netherlands (Recruiting)
Study contacts
- Principal investigator: Maarten Bot, MD PhD — Amsterdam UMC
- Study coordinator: Maarten Bot, MD PhD
- Email: m.bot@amsterdamumc.nl
- Phone: 0031621514048
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.