Mood-state classifiers to guide brain stimulation for treatment-resistant bipolar depression

Who could benefit from this research

What this research studies

Researchers at Baylor College of Medicine will test a sensing-enabled deep brain stimulation approach targeting the ventral capsule/ventral striatum in people with treatment-resistant bipolar depression. They will collect neural signals from the brain along with high-density behavioral data from wearables and smartphones to identify mood states and transitions in real time. The study aims to see if this approach is safe and can help shift patients away from depressive or manic states toward more stable mood and daily functioning. Data from real-time monitoring could inform personalized interventions to improve long-term outcomes for bipolar disorder.

Why it matters

Where this research is happening

• Baylor College of Medicine
  Houston, United States Active

Researchers

• Principal investigator: Goodman, Wayne K — Baylor College of Medicine
• Study coordinator: Goodman, Wayne K

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.