Condition

Drug Resistant Epilepsy clinical trials and research

• 29Clinical trials
• 11NIH research projects
• 1New in 30 days
• 10Countries

Newest Drug Resistant Epilepsy clinical trials

All recruiting trials (29)

• Modified ketogenic diet for adults with drug-resistant epilepsy

  This study tests whether a modified ketogenic diet can help adults with drug-resistant epilepsy see fewer seizures and feel better overall.

  Recruiting Karolinska Institutet · Stockholm · NCT07878104

• Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

  This study tests whether low intensity focused ultrasound can help reduce seizures in adults with drug‑resistant epilepsy.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07680842

• iVEAcare Neuromodulation System for drug‑resistant epilepsy: a feasibility look

  This study tests whether the iVEAcare neuromodulation system is safe and can help reduce seizures and improve quality of life in people with drug‑resistant epilepsy.

  Recruiting at 7 sites iVEAcare · Herston, Queensland and 6 other locations · NCT07640191

• Real-world use of the OneRF Ablation System for epilepsy

  This registry collects real-world outcomes and device performance from patients with drug-resistant epilepsy who are treated with SEEG-guided RF ablation using the OneRF system.

  Recruiting at 3 sites NeuroOne Medical Technologies Corporation · Miami, Florida and 2 other locations · NCT07546253

• Overnight Temporal Interference Stimulation for Temporal Lobe Epilepsy

  This study tests whether overnight, non-invasive temporal interference stimulation to the hippocampus can reduce seizure-related brain activity and improve sleep in adults with drug-resistant temporal lobe epilepsy.

  Recruiting Duke University · Durham, North Carolina · NCT07434986

• Biomarkers of Response to SEEG Thermocoagulation

  This study tests biomarkers to see if they predict how well SEEG-guided radiofrequency thermocoagulation helps people with drug-resistant focal epilepsy.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT07399327

• Infrared light therapy hat for adults with drug-resistant epilepsy

  This will try an infrared red-light therapy hat in adults with drug-resistant epilepsy to see if it reduces seizures and is comfortable to wear.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT07145489

• PET‑MRI mapping of brainstem serotonin pathways in adults with Dravet syndrome

  This uses a PET‑MRI scan with the tracer [18F]MPPF to see if serotonin pathways in the brainstem differ in adults with Dravet syndrome compared with healthy controls.

  Recruiting Hospices Civils de Lyon · Bron, Rhone · NCT07013331

• Gut–brain microbiota link in new‑onset and drug‑resistant epilepsy

  This project will see if gut bacteria and their chemical products are linked to how well people with new‑onset or drug‑resistant epilepsy do after surgery, vagus‑nerve stimulation, or a ketogenic diet.

  Recruiting Niguarda Hospital · Milan, Lombardy · NCT07010445

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Non-invasive brain stimulation for drug-resistant epilepsy

  This study is testing a new non-invasive brain stimulation technique for people aged 6-60 with drug-resistant epilepsy to see if it can help control their seizures better than current treatments.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06708143

• Investigating non-invasive brain stimulation for drug-resistant epilepsy

  This study is testing a new non-invasive brain stimulation method to see if it can help people aged 14-60 with epilepsy that doesn't respond to medication.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06663969

• Exploring brain areas causing drug-resistant epilepsy using advanced imaging techniques

  This study is trying to find out more about the brain areas that cause drug-resistant epilepsy in adults by using advanced imaging techniques.

  Recruiting Xijing Hospital · Xi'an · NCT06557720

• Evaluating a new ultrasound treatment for drug-resistant epilepsy

  This study is testing a new ultrasound treatment for people with drug-resistant epilepsy to see if it can help reduce their seizures and improve their quality of life.

  Recruiting NaviFUS Corporation · Taipei · NCT06492720

• Decoding brain signals for motor control in epilepsy patients

  This study is testing a brain-computer interface to see if it can help people with drug-resistant epilepsy control their hand movements using brain signals.

  Recruiting Research Center of Neurology, Russia · Moscow · NCT06432907

• Low-intensity focused ultrasound treatment for drug-resistant epilepsy

  This study is testing if low-intensity focused ultrasound can help people with drug-resistant temporal lobe epilepsy have fewer seizures while they continue taking their regular medications.

  Recruiting at 3 sites Phase 1/2 NaviFUS Corporation · Palo Alto, California and 2 other locations · NCT06388707

• Personalized electrical stimulation for drug-resistant epilepsy

  This study is testing if a personalized electrical stimulation treatment can help people with drug-resistant epilepsy have fewer seizures and improve their quality of life.

  Recruiting at 3 sites Assistance Publique Hopitaux De Marseille · Bordeaux and 6 other locations · NCT06334952

• Evaluating the ketogenic diet's effects on children with various conditions

  This study is testing if the ketogenic diet can help children with conditions like epilepsy, autism, migraines, and brain tumors feel better and grow properly.

  Recruiting at 3 sites Danone Nutricia SpA Società Benefit · Milan, MI and 2 other locations · NCT06309251

• Using focused ultrasound to treat drug-resistant epilepsy

  This study is testing whether focused ultrasound can help people with drug-resistant epilepsy by reducing their seizures when other medications haven't worked.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT06292494

• Improving MRI for identifying networks in drug-resistant epilepsy

  This study is testing new MRI techniques to see if they can better identify the brain networks causing seizures in people with drug-resistant epilepsy.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT06059157

• Using focused ultrasound to treat drug-resistant epilepsy

  This study is testing a new noninvasive ultrasound treatment for people with drug-resistant temporal lobe epilepsy to see if it can help control their seizures and improve their quality of life.

  Recruiting Genovate Biotechnology Co., Ltd., · Melbourne, Victoria · NCT05947656

• Using ketone esters to treat drug-resistant epilepsy in children

  This study is testing if ketone esters can help children with drug-resistant epilepsy control their seizures better than the traditional ketogenic diet.

  Recruiting Phase 2/3 Sohag University · Sohag · NCT05670847

• Mapping social cognition in epilepsy patients

  This study is trying to see how epilepsy affects social thinking by comparing brain scans and tests of social skills in people with epilepsy and healthy individuals before and after surgery.

  Recruiting Assistance Publique - Hôpitaux de Paris · Gif-sur-Yvette and 1 other locations · NCT05527093

• Understanding Inhibitory Neurotransmission in Drug-Resistant Epilepsy

  This study is testing how certain brain receptors work in people with drug-resistant epilepsy to see if new treatments can help manage their condition better.

  Recruiting Neuromed IRCCS · Pozzilli, Isernia · NCT05459090

• Linking anxiety symptoms to deep brain activity

  This will try to see if brain recordings taken during presurgical monitoring in adults with drug‑resistant epilepsy reveal patterns tied to generalized anxiety disorder.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT05393518

• Mindfulness program to improve quality of life in patients with drug-resistant epilepsy

  This study is testing whether a mindfulness program can help improve the quality of life for people with drug-resistant epilepsy.

  Recruiting University Hospital, Grenoble · Grenoble and 2 other locations · NCT04126369

• Comparing MEG and EEG for locating the source of epilepsy before surgery

  This study is testing whether a new brain scanning method called MEG works better than a traditional method called EEG to find the source of seizures in people with epilepsy who might need surgery.

  Recruiting Hospices Civils de Lyon · Bron · NCT03893916

• Using focused ultrasound to treat drug-resistant epilepsy

  This study is testing a new ultrasound treatment for people with drug-resistant epilepsy to see if it can help reduce their seizures without using medication.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT03868293

• How seizures affect brain wiring in children with focal epilepsy

  This project tests whether ongoing seizures change the brain's white-matter wiring in children with drug-resistant focal epilepsy who are being evaluated for surgery.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT03268824

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Single-pulse brain stimulation to improve epilepsy surgery outcomes

  A new approach uses single-pulse electrical stimulation to better locate seizure-causing brain regions before epilepsy surgery, with the goal of improving chances of seizure freedom.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11448236

• New MRI markers to find seizure zones in hard-to-treat epilepsy

  Aims to use advanced MRI measures of brain stiffness and blood flow to better locate seizure regions in people with drug-resistant epilepsy.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11432253

• Mapping hidden brain cell changes in drug-resistant epilepsy

  This project looks for tiny genetic changes in brain cells of children with drug-resistant epilepsy caused by brain malformations to help guide better diagnosis and treatments.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11263699

• Finding seizure-causing brain regions in drug-resistant epilepsy using computer models

  This project uses computer models of brain activity to help doctors find the areas that start seizures in people whose epilepsy does not respond to medicines.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11263641

• Noninvasive brain mapping to find seizure networks in children with hard-to-treat epilepsy

  This project uses noninvasive brain recordings and connectivity maps to help locate seizure-causing networks in children whose epilepsy does not respond to medication.

  NIH research Cook Children's Medical Center · Fort Worth, United States · NIH-11238074

• Closed-loop implant to target seizure-related high-frequency brain waves in drug-resistant epilepsy

  An implantable device will try to find and interrupt seizure-related high-frequency brain waves in people whose seizures don't respond to medicines.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11097353

• Improving care for patients with drug-resistant epilepsy

  This study is all about creating a helpful mobile app that makes it easier for people with drug-resistant epilepsy to share what matters most to them with their doctors, like their mental health and daily life, so they can work together to improve their overall care.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11067774

• Genetics of drug-resistant epilepsy with focal cortical dysplasia

  Researchers will study the genetic factors behind drug-resistant epilepsy caused by focal cortical dysplasia to uncover what goes wrong in the brain.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11042860

• Mapping brain connections in children with drug-resistant epilepsy

  This study is looking at safe ways to understand how different parts of the brain connect in kids with hard-to-treat epilepsy, so we can create better treatment plans and improve their care without needing any surgery.

  NIH research Cook Children's Medical Center · Fort Worth, United States · NIH-11031315

• Identifying brain networks involved in drug-resistant epilepsy

  This study is looking to help people with drug-resistant epilepsy by finding out exactly where in the brain their seizures come from, using advanced technology to analyze brain activity, which could lead to better surgery results for those who need it.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11017819

• Understanding brain cell changes in children with drug-resistant epilepsy

  This study is looking at how certain changes in brain cells might cause epilepsy in children that doesn't respond to usual treatments, with the hope of finding better ways to diagnose and treat these kids.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11004033

Related topics

Quick answers

How many Drug Resistant Epilepsy clinical trials are recruiting right now?

29, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in France (8 trials), United States (6 trials), Italy (4 trials), China (3 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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