Frequency-specific stimulation of subthalamic nucleus subregions to improve inhibitory control in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with idiopathic Parkinson's disease who meet indications for DBS will receive sequential stimulation conditions targeting either the motor or associative subregions of the subthalamic nucleus at 5 Hz or 130 Hz, plus a no-stimulation control. During each condition they will perform cognitive tasks that measure inhibitory control to compare performance across frequencies and contact locations. The design compares within-subject effects of frequency and subregion to identify patterns that improve or worsen inhibitory control. Results will inform whether specific frequency–subregion combinations produce reliably better cognitive outcomes in the acute setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 40-80 years old;
2. Diagnosed with idiopathic Parkinson's disease;
3. Meeting the indications for DBS surgery.

Exclusion Criteria:

1. Patient declined to participate in the study;
2. Presence of significant post-DBS complications (e.g., intracranial hemorrhage, cerebral edema, electrode misplacement);
3. Significant psychiatric disorders or dementia (MMSE score \<20 for uneducated; \<23 for 1-6 years education; \<27 for ≥7 years education);
4. Visual or auditory impairment affecting cognitive task performance
5. History of conditions potentially impairing cognitive function.

Where it's running

• Beijing Tiantan Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Jianguo Zhang, M.D., Ph.D. — Beijing Tiantan Hospital
• Study coordinator: Hutao Xie
• Email: xieht0123@163.com
• Phone: +8618756921517

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.