Condition

Tourette Syndrome clinical trials and research

• 19Clinical trials
• 21NIH research projects
• 6Countries

Newest Tourette Syndrome clinical trials

All recruiting trials (19)

• Nature- and activity-based group programs for neurodivergent children and youth in Agder

  This project will try outdoor and activity-based group programs to see if they help children and teens with ADHD, autism, Tourette's, and related neurodivergent challenges feel better, gain confidence, and do better in daily life.

  Recruiting at 2 sites Sorlandet Hospital HF · Kristiansand, Agder and 1 other locations · NCT07203469

• Study of brain activity in patients with Tourette Syndrome

  This study is testing how brain activity changes in adults with severe Tourette Syndrome who are getting deep brain stimulation to better understand their tics.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT06909656

• Personalized deep brain stimulation for Tourette syndrome

  This study is testing if personalized deep brain stimulation can help people with Tourette syndrome reduce their tics and improve related issues like anxiety and attention problems.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06889480

• Cognitive-psychophysiological therapy, with or without biofeedback, for tics in young people with Tourette's

  This project tests whether adding biofeedback to cognitive-psychophysiological therapy helps reduce tics in 14–21-year-olds with Tourette's.

  Recruiting Université du Québec a Montréal · Montreal, Quebec · NCT06873841

• Personalized neurostimulation for Tourette's Syndrome

  This study is testing a personalized brain stimulation treatment for adults with Tourette's Syndrome who haven't found relief from other therapies to see if it can help reduce their severe tics.

  Recruiting Xuanwu Hospital, Beijing · Beijing · NCT06785532

• Understanding changes in Tourette Syndrome

  This study is trying to learn how Tourette Syndrome and tic disorders change over time in kids by using new technology to track their symptoms.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT06679790

• Treatment for chronic tics in youth using behavioral therapy and brain stimulation

  This study is testing whether combining a special therapy for tics with a type of brain stimulation can help young people with Tourette Syndrome better control their tics.

  Recruiting Phase 2 University of Minnesota · Minneapolis, Minnesota · NCT06678737

• Registry for pediatric deep brain stimulation outcomes

  This study is creating a database to collect information on how deep brain stimulation helps children with movement disorders like dystonia and Tourette syndrome, to see how safe and effective the treatment is.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06585618

• Understanding the experiences of adolescents with tic disorders

  This study looks at the experiences of teenagers with tic disorders to see how their tics and other feelings affect their daily lives and mental health.

  Recruiting Vanderbilt University Medical Center · Nashvile, Tennessee · NCT06576726

• Mindfulness intervention for managing tics in Tourette syndrome

  This study is testing a mindfulness program to see if it can help adults with Tourette syndrome manage their tics better than traditional therapy.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT06408662

• Internet-based behavior therapy for adults with Tourette syndrome

  This study is testing whether an online behavior therapy can help adults with Tourette syndrome reduce their tics and improve their overall well-being compared to general support.

  Recruiting Karolinska Institutet · Stockholm · NCT06271083

• Understanding how kids respond to a behavioral intervention for tics

  This study is testing a program called CBIT to see if it can help kids aged 10-17 manage their tics better.

  Recruiting at 2 sites Phase 2 University of Minnesota · San Diego, California and 1 other locations · NCT06194305

• Assertiveness and emotion-management difficulties in adults with Tourette syndrome

  This will test how common assertiveness difficulties are in adults with Tourette syndrome by asking them to complete online questionnaires.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, France · NCT06136572

• Comparing Sertraline and Placebo for Treating Anxiety in Children with Neurodevelopmental Disorders

  This study is testing if the medication sertraline can help reduce anxiety in children and teens aged 8-17 with neurodevelopmental disorders like autism and Fragile X syndrome compared to a placebo.

  Recruiting at 6 sites Phase 2 Holland Bloorview Kids Rehabilitation Hospital · Calgary, Alberta and 6 other locations · NCT06081348

• Using TMS to enhance behavioral therapy for Tourette Syndrome

  This study is testing if adding a brain stimulation treatment to behavioral therapy can help adults with Tourette Syndrome reduce their tics more effectively.

  Recruiting West Virginia University · Morgantown, West Virginia · NCT05705999

• Examining the effects of stress on adults with Tourette Syndrome

  This study looks at how stress affects adults with Tourette Syndrome over two years to see if it changes their tics, mental health, and overall quality of life.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04851678

• Observational database on deep brain stimulation for Tourette syndrome

  This study looks at how deep brain stimulation helps people with Tourette syndrome by tracking their tic severity and overall well-being for five years after surgery.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04449068

• Observing sensory symptoms in Tourette syndrome

  This study looks at how sensory symptoms affect people with Tourette syndrome over time by having them fill out questionnaires about their experiences each year.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee and 1 other locations · NCT03851484

• Using washed microbiota transplantation to treat Tourette's syndrome

  This study is testing whether a new treatment that involves transferring healthy gut bacteria can help people with Tourette's syndrome feel better.

  Recruiting at 2 sites Phase 1 The Second Hospital of Nanjing Medical University · Nanjing, Jiangsu and 1 other locations · NCT03764748

NIH-funded research (21)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Precision brain mapping of tics in children with Tourette syndrome

  A new study uses advanced MRI to map brain activity in individual kids with Tourette syndrome to understand why tics differ from child to child.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11365439

• Digital tic-detection partner to support Tourette syndrome therapy

  A computer vision system will help detect tics in children and youths with Tourette syndrome to support behavioral therapy at home and in real life.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11359761

• Quantifying Tourette tics with video and computer tools

  This project aims to develop and test video-based, automated ways to measure tic severity in people with Tourette Syndrome.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11333220

• Brain-feedback training to help teens with Tourette control tics

  This project teaches teenagers with Tourette syndrome to use real-time MRI brain-feedback to change activity in a motor brain area with the goal of reducing tics.

  NIH research Yale University · New Haven, United States · NIH-11308704

• International collaboration mapping genes and brain scans in Tourette syndrome

  This project brings together MRI brain scans and genetic data from people with Tourette syndrome and related conditions to spot biological patterns linked to tics and co-occurring symptoms.

  NIH research Purdue University · West Lafayette, United States · NIH-11250036

• How Tourette syndrome develops in the brain

  Researchers are using donated brain tissue and patient-derived stem cells to learn why people with Tourette syndrome have fewer specific brain cells in the basal ganglia.

  NIH research Yale University · New Haven, United States · NIH-11249573

• Investigating brain imaging and cognitive markers in children with Tourette syndrome

  This study is looking at how Tourette syndrome affects kids by using brain scans and tests over time to see how their brain functions change as they grow, with the goal of finding ways to help manage their symptoms better.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11197120

• Detecting and stopping tics with targeted deep brain stimulation for Tourette syndrome

  Adaptive deep brain stimulation devices will be implanted in people with severe, treatment-resistant Tourette syndrome to detect brain signals tied to tics and automatically reduce those tics.

  NIH research University of Florida · Gainesville, United States · NIH-11182641

• Understanding social isolation and cognition in adolescents with Tourette syndrome

  This study looks at how feeling alone affects teenagers with Tourette syndrome and how well they understand social situations, hoping to find ways to help them connect better with others.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11137898

• Measuring Tics in Tourette Syndrome

  This study is looking for ways to use video technology to better measure and understand the tics that people with Tourette Syndrome experience, so we can improve how we diagnose and treat the condition.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11083111

• Understanding the neurodevelopment of Tourette syndrome

  This study is looking at how genes and brain development might affect Tourette syndrome by examining brain tissue and special lab-grown brain cells, with the goal of finding out what causes TS and how we can better treat it.

  NIH research Yale University · New Haven, United States · NIH-11048424

• Understanding sensory sensitivity in Tourette Syndrome

  This study is looking into how people with Tourette Syndrome, both kids and adults, react strongly to sensory experiences, like sounds or textures, to better understand why this happens and how it affects their daily lives.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11039948

• Training adolescents with Tourette Syndrome to control brain activity

  This study is testing a brain training program to help teenagers with Tourette Syndrome learn to control a part of their brain that affects their tics, using fun techniques like imagining relaxing scenes or practicing movements, to see if it can help them manage their symptoms better.

  NIH research Yale University · New Haven, United States · NIH-11036355

• Investigating the genetics and brain imaging of Tourette Syndrome

  This study is looking at how Tourette Syndrome affects kids by exploring their genes and brain activity, with the goal of finding better treatments, and it invites children with TS to help by sharing samples and taking part in brain scans.

  NIH research Purdue University · West Lafayette, United States · NIH-11005775

• A Computer Vision System to Help Patients with Tourette Syndrome Manage Tics

  This project is creating a smart digital tool to help people with Tourette Syndrome practice managing their tics at home.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10930961

• Identifying brain targets to help control tics in Tourette syndrome using deep brain stimulation

  This study is exploring a new way to help people with Tourette syndrome by using a special device that can adjust its treatment based on their tics, aiming to find the best spots in the brain to reduce those tics for those who haven't found relief with other methods.

  NIH research University of Florida · Gainesville, United States · NIH-10917124

• Understanding how tics change over time in Tourette Syndrome

  This study is looking at how tic symptoms change over time in kids and teens with Tourette Syndrome, using cool tools like apps and wearables to gather information, so we can find better ways to help manage their tics and improve their treatment.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10865360

• Investigating brain imaging and cognitive markers in children with Tourette syndrome

  This study is looking at how brain scans and thinking skills are connected to Tourette syndrome in kids, and it aims to see how their brain changes over time while they deal with their tics and everyday life.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10845459

• Using computer vision to identify tics in people with Tourette Syndrome

  This study is working on a smart system that can spot and understand tics in people with Tourette Syndrome while they do different activities, with the goal of helping them practice behavior therapy skills more easily and effectively, even without a human partner.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10817272

• Investigating how neuroactive steroids affect Tourette syndrome

  This study is looking at how certain brain chemicals might affect the symptoms of Tourette syndrome, especially in boys, and how stress can make tics worse, with the hope of finding new ways to help manage the condition.

  NIH research University of Utah · Salt Lake City, United States · NIH-10656348

• Investigating a gene linked to Tourette syndrome

  This study is looking at how a specific gene called CELSR3 might be linked to Tourette syndrome, using special mice to see how changes in this gene could help us understand the condition better and find new treatments for people with TS.

  NIH research University of Utah · Salt Lake City, United States · NIH-10532254

Related topics

Quick answers

How many Tourette Syndrome clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (9 trials), China (3 trials), France (3 trials), Canada (2 trials), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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