Adaptive Deep Brain Stimulation for Parkinson's Disease

Who could benefit from this research

What this research studies

This project explores a new adaptive deep brain stimulation system for Parkinson’s disease. Researchers will validate the investigational device and obtain regulatory approvals, then identify brain signals linked to motor symptoms and sleep. Finally, they will test a sleep-aware, pallidal adaptive stimulation approach in a short, blinded crossover trial to see if personalized stimulation improves symptoms and daily function. The study aims to generate early safety and feasibility data to guide future trials and potential improvements in how DBS treats Parkinson’s.

Why it matters

Where this research is happening

• University of Florida
  Gainesville, United States Active

Researchers

• Principal investigator: Gunduz, Aysegul — University of Florida
• Study coordinator: Gunduz, Aysegul

Related research

Other NIH-funded projects on the same topics.

• Adaptive deep brain stimulation to help Parkinson's patients respond to daily changes

  A new, smarter brain stimulation approach for Parkinson’s disease aims to automatically adjust therapy throughout the day to better control symptoms.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11472896

• TinyML-powered closed-loop DBS for Parkinson's disease

  A small, energy-efficient brain-stimulation system using lightweight AI runs on an implanted device to adapt DBS in real time for people with Parkinson's disease.

  NIH research Michigan Technological University · Houghton, United States · NIH-11444690

• Theta Burst Deep Brain Stimulation for Cognitive and Motor Benefits in Parkinson’s-Related Dementia

  A study from USC will test a new brain stimulation approach to help people with Parkinson’s disease and Lewy body dementia improve thinking skills and movement.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11396247

• Spatiotemporal Tuning of Deep Brain Stimulation for Parkinson’s Disease

  Aims to personalize deep brain stimulation by adjusting where and when the brain is stimulated to better control Parkinson’s symptoms.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11362362

• Understanding sleep problems in Parkinson’s disease using at-home brain recordings and adaptive stimulation

  Scientists are testing how brain signals during sleep relate to sleep problems in Parkinson’s and whether a special DBS device at home can improve sleep by adapting stimulation.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11330586

• Subthalamic Deep Brain Stimulation to Help with Visuo-Vestibular Conflicts in Parkinson's

  A study to improve how people with Parkinson's use visual and balance cues when moving, by optimizing deep brain stimulation in the subthalamic nucleus to help navigation and balance.

  NIH research Cleveland VA Medical Research/ed/fdn · Cleveland, United States · NIH-11304149

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.