Blood-based predictors of DBS outcomes for Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study collecting blood samples and routinely discarded brain tissue from patients undergoing DBS for Parkinson's disease, without changing the surgical procedure. Investigators will measure proteomic, transcriptomic, and genomic markers and link them to clinical outcomes including motor, axial, non-motor symptoms, medication changes, activities of daily living, and quality of life. Samples and clinical data will be compared before and after DBS to identify markers associated with good versus poor response and to track longitudinal changes. The team will combine multiomic profiles with clinical features to build an explainable AI model to predict and stratify DBS response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Diagnosis of "Clinically Established PD" as defined by the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (MDS-PD criteria)
2. Referred for DBS according to standard local clinical guidelines 2a. Significant motor complications despite optimized pharmacological treatment 2ai. UPDRS motor score \>30/108 in the off-medication state 2aii. Hoehn and Yahr staging \>2.5/5 in the off-medication state 2b. Dopamine responsive 2bi. \>33% improvement in UPDRS motor score after levodopa administration 2c. Age ≤75 years 2d. No contraindication to surgery or other significant comorbidity with limited life expectancy 2e. No significant psychiatric problems or cognitive impairment 2f. No structural lesions or features suggestive of atypical parkinsonism or other mimickers of idiopathic PD on neuroimaging

Exclusion Criteria:

1. Unwilling to undergo blood sampling for study purposes
2. Evidence of Parkinsonism due to heavy metal exposure
3. History of neurodevelopmental disorder, neurodegenerative disease other than PD, CNS infection, neuroinflammatory disease (e.g. multiple sclerosis, CNS lupus), malignancy within the last 10 years, cerebrovascular accident, HIV infection, systemic autoimmune disease, alcohol dependence or other substance use
4. Unable to pass DBS pre-operative assessment or unwilling to undergo DBS

Where it's running

• The Hong Kong University of Science and Technology
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Nancy Ip — The Hong Kong University of Science and Technology
• Study coordinator: Nancy Ip
• Email: boip@ust.hk
• Phone: 852-23587304

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.