Condition

PARKINSON DISEASE (Disorder) clinical trials and research

• 48Clinical trials
• 2New in 30 days
• 21Countries

Newest PARKINSON DISEASE (Disorder) clinical trials

All recruiting trials (48)

• UX-DA003 injections for Parkinson's disease

  This early-phase trial tests whether injecting UX-DA003 is safe and may help motor symptoms in people with Parkinson's whose response to standard treatments has declined.

  Recruiting Early Phase 1 The First Affiliated Hospital of Anhui Medical University · Hefei, Anhui · NCT07911670

• Strength and dual-task training to help people with Parkinson’s improve strength and function

  This trial tests three levels of physiotherapy, including progressive resistance training with and without cognitive dual-task and instability components, to see if they improve muscle strength, body composition, and physical function in adults with Parkinson’s or related syndromes.

  Recruiting University of Valencia · Valencia, Valencia · NCT07907302

• Spinal Mobility, Rigidity, and Kinesiophobia in Parkinson's Disease with and without TMD

  This study tests whether people with Parkinson's disease who have Temporomandibular Disorders differ in spinal mobility, axial rigidity, and kinesiophobia from those without TMD.

  Recruiting Mustafa Kemal University · Hatay · NCT07850674

• A 12-Week Trial of Flexilev with the OraFID Device and App for Parkinson's

  This study tests whether taking small, precise doses of Flexilev with the OraFID dosing device and Levilog app is acceptable and helps people with Parkinson's manage their medicine.

  Recruiting at 2 sites Phase 4 Navamedic AB · Stockholm, Stockholm County and 4 other locations · NCT07839793

• Integrated Motor-Cognitive Training in Parkinson's Disease

  This study tests a combined motor and cognitive rehabilitation program to see if people with Parkinson’s disease can stick with it and show early signs of benefit.

  Recruiting University Hospital of Ferrara · Ferrara, FE · NCT07833748

• VIM0423 for Parkinson's Tremor in Adults Not Fully Controlled by Dopaminergic Therapy

  A Vima Therapeutics study tests whether the oral drug VIM0423 can reduce tremor in adults with Parkinson’s disease who still have tremor despite dopaminergic treatment.

  Recruiting at 4 sites Phase 2 Vima Therapeutics · Scottsdale, Arizona and 29 other locations · NCT07804615

• Optimizing Adaptive Deep Brain Stimulation for Parkinson's Disease

  This study tests whether using ongoing brain signals gathered during daily life can improve adaptive deep brain stimulation for people with Parkinson's who have motor fluctuations.

  Recruiting University of California, Davis · Davis, California · NCT07798271

• Wearable sensors to track tremor and daily movement in Parkinson’s disease and essential tremor

  A wearable sensor study will test how tremor and upper-limb movement look in adults with Parkinson’s or essential tremor, using sensors worn at clinic and at home.

  Recruiting Heriot-Watt University · Edinburgh, Edinburgh · NCT07787299

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• Seeing how the Short Physical Performance Battery works for people with Parkinson's in Galicia

  This study tests whether the Short Physical Performance Battery (SPPB) is reliable and valid for adults with Parkinson's disease living in Galicia, Spain.

  Recruiting at 2 sites University of Vigo · Pontevedra, Pontevedra and 1 other locations · NCT07780461

• Safinamide added to standard therapy for PD-related pain

  This Phase 3 trial tests whether safinamide, added to usual Parkinson’s medication, reduces PD-related pain more than placebo in adults with motor fluctuations and chronic pain.

  Recruiting Phase 3 Universita di Verona · Verona, Veneto · NCT07761936

• See if deep brain stimulation for Parkinson's changes thinking and movement and affects fall risk

  This pilot study tests whether deep brain stimulation in people with Parkinson’s changes thinking or movement and whether those changes relate to how often they fall.

  Recruiting University of Alabama at Birmingham · Homewood, Alabama · NCT07725315

• Early diagnosis of Parkinson's using digital and neurogenic exosome biomarkers

  This study tests whether digital biomarkers from wearable devices and neurogenic exosome biomarkers in blood can help identify Parkinson's disease earlier, by comparing healthy individuals, people at prodromal risk, and those with early Parkinson's.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07679256

• MF1: a first-in-human test in healthy men and people with Parkinson's disease

  This early study tests MF1 to see if it is safe and how it behaves in the body, first in healthy Japanese men and then in people with Parkinson's disease- related symptoms.

  Recruiting Phase 1 University of Shizuoka · Sumida-ku, Tokyo · NCT07666022

• Tai Chi vs Qi-Gong for early-stage Parkinson’s patients

  A randomized study tests whether Tai Chi therapy or Qi-Gong can improve balance and motor function in people with early-stage Parkinson’s disease.

  Recruiting at 2 sites Lahore University of Biological and Applied Sciences · Lahore, Punjab Province and 1 other locations · NCT07662837

• Feasibility of a community-based, personalized multimodal exercise program for Parkinson's disease

  A 12-week, group-based but individually tailored exercise program is being tested in people with Parkinson's to see if it can be feasibly delivered in a community setting and whether it shows preliminary benefits.

  Recruiting Universidad Rey Juan Carlos · Alcorcón, Madrid · NCT07618728

• Tracking physical activity changes in people with Parkinson's

  This project will follow about 450 people with Parkinson's over four years using wearable activity monitors, clinical tests, and questionnaires to see which physical, cognitive, social, or environmental factors make people less active.

  Recruiting Karolinska Institutet · Stockholm · NCT07585409

• Gut-brain in PD Consortium: understanding gut influences in Parkinson's and prodromal stages

  This study tests how the gut and brain communicate in people with Parkinson's, those without PD, and those at risk, to see if gut factors relate to disease onset and progression.

  Recruiting at 4 sites Duke University · Stanford, California and 6 other locations · NCT07567794

• Ear vagus nerve stimulation to improve heart rate and blood pressure control in Parkinson's disease

  This study will see if gentle ear-based vagus nerve stimulation can help people with Parkinson's disease better control their heart rate and blood pressure.

  Recruiting Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT07557706

• Accelerated rTMS for Motor and Thinking in Parkinson's

  This pilot study tests whether a fast, intensive course of rTMS aimed at the motor cortex can help with movement and thinking abilities in adults with mild-to-moderate Parkinson's disease.

  Recruiting San Francisco Neurology and Sleep Center · San Francisco, California · NCT07554833

• Independent walking program with or without walking poles for people with Parkinson disease

  This study will test whether an 8-week independent walking program using walking poles helps people with Parkinson disease improve their walking compared with walking without poles.

  Recruiting East Tennessee State University · Johnson City, Tennessee · NCT07551661

• Steady Together: a home fall-prevention program for people with Parkinson's

  This program will try an occupational therapy–led home visit and online tools to reduce fall risk and increase safety confidence for people with Parkinson's who are InMotion members.

  Recruiting Cleveland State University · Beachwood, Ohio · NCT07519096

• Home-based remote temporal interference stimulation for motor problems in Parkinson's disease

  This trial will test whether daily, remotely supervised home temporal interference brain stimulation can help movement problems like slowness, stiffness, and walking difficulty in people with Parkinson's disease.

  Recruiting Shanghai University of Sport · Shanghai, Shanghai Municipality and 1 other locations · NCT07518290

• Aerobic training to improve brain blood flow, thinking, and walking in Parkinson's

  This will test whether a 12-week supervised aerobic exercise program improves cerebral blood flow, cognition, and gait in people with Parkinson's disease (Hoehn & Yahr stages 1–3).

  Recruiting University of Nove de Julho · São Paulo, São Paulo · NCT07478146

• Precision medicine approach for diagnosing and treating Parkinson's, Alzheimer's, and type 2 diabetes

  This project will test whether genetic, metabolic, epigenetic and brain-imaging patterns can help diagnose and guide care for people with Parkinson's disease, Alzheimer's disease, or type 2 diabetes.

  Recruiting Neuromed IRCCS · Pozzilli · NCT07467460

• IRL757 for treating apathy in Parkinson's disease.

  This study will test whether the medication IRL757 is safe, easy to tolerate, and helps reduce apathy in people aged 50–90 with Parkinson's disease.

  Recruiting at 12 sites Phase 1/2 Integrative Research Laboratories AB · Pleven and 13 other locations · NCT07461220

• Understanding How Priors Influence Hallucinations in Parkinson’s

  Researchers test whether expectations make people with Parkinson’s hallucinate more during a simple visual task than those without hallucinations.

  Recruiting at 2 sites University Hospital, Grenoble · Grenoble and 1 other locations · NCT07427498

• Single-dose SER-252 treatment for people with Parkinson's disease and motor fluctuations

  This study will try a single subcutaneous dose of SER-252 versus placebo in adults with Parkinson's disease who have motor fluctuations and at least 2 hours of daily OFF time.

  Recruiting at 5 sites Phase 1 Serina Therapeutics · Englewood, Colorado and 5 other locations · NCT07422675

• Brain activity linked to motor and psychiatric ups and downs in Parkinson's

  The study will see if EEG and recordings from patients' subthalamic deep brain stimulator can reveal brain signals tied to motor and psychiatric fluctuations in people with Parkinson's who are on dopaminergic therapy and recently had STN‑DBS.

  Recruiting University Hospital, Geneva · Geneva · NCT07404241

• EarStim for short- and long-term relief of Parkinson's motor symptoms

  This study tests whether a wearable EarStim device can give intermittent short- and long-term relief of motor symptoms in adults with moderate-to-severe Parkinson's disease who experience wearing-off.

  Recruiting Stoparkinson Healthcare Systems LLC · Istanbul and 1 other locations · NCT07400731

• Robotic upper-limb therapy with built-in cognitive exercises for people with Parkinson's, MS, or stroke

  This trial will test whether sensor-based robotic arm training that includes thinking exercises can help adults with Parkinson's disease, multiple sclerosis, or stroke improve attention, memory, and arm movement.

  Recruiting IRCCS Centro Neurolesi Bonino Pulejo · Messina, Maine · NCT07384143

• Blood-based predictors of DBS outcomes for Parkinson's disease

  This project will test whether proteins and RNA in blood can predict how people with Parkinson's disease will respond to deep brain stimulation (DBS).

  Recruiting Hong Kong University of Science and Technology · Hong Kong · NCT07376278

• How walking skills transfer from split-belt treadmill to overground walking in Parkinson's

  This project will test whether stimulating a brain area called the posterior parietal cortex with repeated TMS helps people with Parkinson's transfer improvements from split-belt treadmill training to normal overground walking.

  Recruiting McGill University · Montreal, Quebec · NCT07351032

• Italian version of the GIDS-PD (Gastrointestinal Dysfunction Scale for Parkinson's disease)

  This project will test an Italian translation of the Gastrointestinal Dysfunction Scale for people with Parkinson's disease to help measure stomach and bowel symptoms.

  Recruiting Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Milan and 4 other locations · NCT07316751

• Daily transcranial pulsed electromagnetic field (T-PEMF) therapy for Parkinson's disease

  This trial tests whether daily 30-minute sessions of transcranial pulsed electromagnetic fields (T-PEMF) help people with early-stage Parkinson's disease.

  Recruiting at 2 sites University of Southern Denmark · Odense and 1 other locations · NCT07306104

• Whole-body light therapy for motor and thinking symptoms in Parkinson's disease

  This trial will test whether about 10 weeks of whole-body photobiomodulation (20 minutes per session, about three times a week) can improve movement and thinking in adults with Parkinson's disease who can walk independently.

  Recruiting Pusan National University Yangsan Hospital · Yangsan, Gyeongsangnam-do · NCT07271927

• Vagus nerve stimulation to improve ankle muscle activity and posture in Parkinson's disease

  This project will test whether non-invasive vagus nerve stimulation at the neck can improve ankle muscle activation, walking, and balance in people with Parkinson's disease.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07226284

• Detecting Parkinson's-related alpha-synuclein in colon tissue taken during routine colonoscopy

  This will see if small extra colon tissue samples taken during a routine colonoscopy can find phosphorylated alpha-synuclein in people with Parkinson's disease or REM sleep behavior disorder.

  Recruiting CND Life Sciences · Branford, Connecticut · NCT07217054

• Detecting phosphorylated alpha-synuclein in colon tissue to help diagnose Parkinson's

  This study will test whether routine colonoscopy tissue samples from adults with Parkinson's show phosphorylated alpha-synuclein, a protein linked to the disease.

  Recruiting CND Life Sciences · Portland, Oregon · NCT07204652

• Motor imagery training to improve hand dexterity and balance in Parkinson's disease

  This program will test whether guided mental imagery exercises can help people aged 40–75 with Parkinson's disease improve hand dexterity and balance.

  Recruiting Kahramanmaras Sutcu Imam University · Kahramanmaraş, Onikişubat · NCT07193355

• Mental imagery to improve arm and hand skills in Parkinson's

  This trial will test whether guided mental imagery exercises can help people with Parkinson's improve arm and hand movement and dexterity.

  Recruiting Kahramanmaras Sutcu Imam University · Kahramanmaraş, Onikişubat · NCT07193303

• Multicontext Approach to Help Daily Thinking in Parkinson’s

  This study tests whether a Multicontext strategy training program can improve daily thinking and function for people with early Parkinson’s who notice cognitive changes.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07190404

• At-home electrical brain stimulation for Parkinson's movement symptoms

  This trial tests a wearable, at-home electrical stimulation device called Sphere V3.0 to see if it improves movement problems in adults with Parkinson's disease.

  Recruiting Phase 1/2 U: The Mind Company · Cleveland, Ohio · NCT07182058

• Intestinal levodopa plus entacapone (Lecigon®) to reduce dopaminergic desensitization and neuropsychiatric complications in Parkinson's

  This trial will try intestinal levodopa plus entacapone (Lecigon®) versus best oral medication in people with Parkinson's who are eligible for Lecigon to see if it reduces hyperdopaminergic symptoms after six months.

  Recruiting at 5 sites Phase 3 University Hospital Tuebingen · Saarlouis, Saarland and 6 other locations · NCT07151378

• Vitamin D3 and brain wave patterns in men with Parkinson's disease and low vitamin D

  This will test whether taking a weekly high-dose vitamin D3 capsule for 8 weeks changes brain wave patterns in men with Parkinson's disease who have low vitamin D levels.

  Recruiting Bangladesh Medical University · Dhaka, Shahbag · NCT07096336

• Group program to manage fatigue and boost energy-conservation confidence for people with Parkinson's disease

  This trial will test whether a group-based fatigue management program helps people with Parkinson's disease feel more confident using energy-conservation strategies compared with receiving standard informational sheets.

  Recruiting Universita degli Studi di Genova · Genova · NCT07094269

• Mediterranean diet for people with Parkinson's disease

  This study will try a Mediterranean diet to see if it helps motor and non-motor symptoms in people with Parkinson's disease.

  Recruiting Università degli Studi dell'Insubria · Varese, Varese · NCT06705517

• Probiotics for depression and mood problems in Parkinson's disease

  This trial will test whether a 12-week oral multi-strain probiotic can improve depressive symptoms in people with Parkinson's disease.

  Recruiting Phase 2 University of British Columbia · Vancouver, British Columbia · NCT05568498

Related topics

Quick answers

How many PARKINSON DISEASE (Disorder) clinical trials are recruiting right now?

48, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (14 trials), Italy (7 trials), Spain (4 trials), Turkey (Türkiye) (4 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 3: 2, Phase 1/2: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →