Investigating non-invasive brain stimulation for drug-resistant epilepsy
Evaluating Modulation Effects of Temporal Interference Using SEEG
NA · Xuanwu Hospital, Beijing · NCT06663969
This study is testing a new non-invasive brain stimulation method to see if it can help people aged 14-60 with epilepsy that doesn't respond to medication.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 14 Years to 65 Years |
| Sex | All |
| Sponsor | Xuanwu Hospital, Beijing (other) |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06663969 on ClinicalTrials.gov |
What this trial studies
This prospective study explores the effects of temporal interference (TI) on deep brain stimulation in patients aged 14-60 with drug-resistant epilepsy. By utilizing stereoelectroencephalography (SEEG), the study aims to analyze the electrophysiological mechanisms of TI, which generates focused stimulation in targeted brain areas without invasive procedures. Clinical, imaging, and electrophysiological data will be collected and analyzed to enhance understanding of TI's impact on brain function and its potential as a treatment alternative.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 14-60 with a clinical diagnosis of drug-resistant epilepsy who have undergone implantation of stereotactic electrodes.
Not a fit: Patients with severe systemic diseases or complications at the electrode site may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a non-invasive treatment option for patients with drug-resistant epilepsy.
How similar studies have performed: While temporal interference is a novel approach, similar studies in non-invasive brain stimulation have shown promising results, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of drug-resistant epilepsy; * No severe systemic diseases; * Implantation of stereotactic electrodes; * Agreement to participate in this study and signs the informed consent form. Exclusion Criteria: * Hematoma at the scalp electrode site or fluid accumulation under the electrode after intracranial electrode placement.
Where this trial is running
Beijing, Beijing Municipality
- Xuanwu Hospital,Capital Medical University — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Principal investigator: Liankun Ren, MD — Xuanwu Hospital, Beijing
- Study coordinator: Liankun Ren, MD
- Email: renlk2022@outlook.com
- Phone: +86 13681576621
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Deep Brain Stimulation, Drug Resistant Epilepsy, Temporal Interference, Stereoelectroencephalography