Condition

s Disease clinical trials and research

• 27Clinical trials
• 3533NIH research projects
• 8Countries

Newest s Disease clinical trials

All recruiting trials (27)

• How physical activity might help people with Parkinson’s disease who have DBS-STN implants

  This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.

  Recruiting Medical University of Warsaw · Warsaw · NCT07838636

• Home-based brain stimulation plus online chair yoga for chronic knee pain in people with Alzheimer's disease

  This project will test whether combining home-based low-intensity brain stimulation (tDCS) with online chair yoga can reduce chronic knee pain in older adults with Alzheimer's disease and related dementias.

  Recruiting University of Arizona · Tucson, Arizona · NCT07303998

• Carotid artery wall viscosity and memory problems in older adults

  This project will test whether the viscous behavior of the carotid artery wall is linked to memory problems in people over 70 with memory complaints, Alzheimer's disease, or vascular dementia.

  Recruiting University Hospital, Rouen · Rouen · NCT07205003

• Measuring phosphorylated tau‑217 (pTau217) in donated blood plasma

  This project will test donated blood plasma to see if some units contain high levels of phosphorylated tau‑217, a marker linked to Alzheimer's disease.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT07157839

• DUVAX: a first-in-human vaccine for amyloid and tau targets in adults 40-65

  A first-in-human vaccine called DUVAX is tested in healthy adults to see if it's safe and whether it triggers an immune response against Alzheimer’s-related proteins.

  Recruiting Phase 1 Nuravax, Inc. · Miami Lakes, Florida · NCT07142278

• Scalp EEG mapping of DBS-induced electric fields

  This will test whether very high–sampling-rate EEG can record the electric fields produced by DBS in people with Parkinson's disease or related movement disorders who already have implants.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT07115394

• GM101 injection to reprogram putamen cells for Parkinson's disease

  This trial will test an experimental gene therapy called GM101, given by brain injection, to see if it is safe for people aged 40–70 with Parkinson's disease lasting five years or more.

  Recruiting Early Phase 1 Genemagic Biosciences Co., Ltd · Changsha · NCT07100171

• Alzheimer's Multinuclear Imaging Neuro-Enhanced Resolution (AD-MINER) cohort

  This project will use 3T and 7T MRI, blood biomarkers, and genetic testing to try to find early brain and sodium changes in people aged 55–90 who are cognitively normal, have mild cognitive impairment, or have Alzheimer's.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07089303

• Ruxolitinib for adults with previously treated idiopathic multicentric Castleman disease

  This trial will try ruxolitinib (Jakafi) in adults with iMCD who did not improve with or cannot take siltuximab or tocilizumab.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07085039

• Targeted mechanical stimulation used at home to relieve tremors

  This project will try a wearable device that delivers targeted mechanical stimulation at home to reduce moderate-to-severe upper limb tremors in adults with essential tremor or Parkinson's disease.

  Recruiting Encora, Inc. · Cambridge, Massachusetts · NCT07078422

• Silkworm pupa powder to improve nutrition in people with Alzheimer's disease

  This trial will see if daily silkworm pupa powder can improve nutrition, muscle loss, weakness, and thinking in people with Alzheimer's disease.

  Recruiting Zhejiang Hospital · Hangzhou, Zhejiang · NCT07059871

• Intestinal ultrasound predicts guselkumab response in moderate-to-severe Crohn's disease

  This project will test whether intestinal ultrasound can help predict if guselkumab will work for adults with moderate-to-severe Crohn's disease.

  Recruiting The Third Xiangya Hospital of Central South University · Changsha, Hunan · NCT07034664

• KDS2010 for people with MCI or mild dementia due to Alzheimer's disease.

  This trial will test whether taking KDS2010 once daily for 24 weeks helps thinking and memory and is safe in people aged 50–85 who are amyloid-positive with MCI or mild Alzheimer's dementia.

  Recruiting at 8 sites Phase 2 NeuroBiogen Co., Ltd · Gwangju, Gwangju and 7 other locations · NCT07027072

• Cervical lymphatic bypass for treating Alzheimer's disease

  This study is testing a new surgery to see if it can help people with mild to moderate Alzheimer's disease by improving the way the brain clears out harmful proteins.

  Recruiting Changi General Hospital · Singapore · NCT06965062

• Using brain stimulation to improve memory and motivation in older adults

  This study is testing if a type of brain stimulation can help improve memory and motivation in older adults, including those showing early signs of Alzheimer's disease.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06956300

• Using brain stimulation to improve memory and motivation in older adults

  This study is testing if a type of brain stimulation can help improve memory and motivation in older adults, including those showing early signs of Alzheimer's disease.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06956300

• Understanding how Deep Brain Stimulation affects Freezing of Gait in Parkinson's Disease

  This study is testing how Deep Brain Stimulation can help people with Parkinson's Disease who struggle with Freezing of Gait by looking at their brain and behavior before and after the treatment.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT06951906

• Lecanemab to boost synaptic plasticity in early Alzheimer's disease

  This study will test whether lecanemab can preserve synaptic function and slow cognitive decline in amyloid-positive people aged 50–90 with mild cognitive impairment or mild Alzheimer's disease.

  Recruiting Xuanwu Hospital, Beijing · Beijing · NCT06871839

• Managing homocysteine levels in Parkinson's patients on levodopa

  This study is testing if giving B vitamins to people with Parkinson's who are taking levodopa can lower their homocysteine levels and improve their thinking skills.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT06772220

• Comparing subcutaneous and intravenous vedolizumab for inflammatory bowel disease with remote monitoring

  This study is testing if a digital health system can help people with inflammatory bowel disease stick to their vedolizumab treatment, whether they receive it through an injection under the skin or through an IV, and how it affects their health over 22 weeks.

  Recruiting at 2 sites Mercy Medical Center · New Orleans, Louisiana and 5 other locations · NCT06750731

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Assessing a new questionnaire for neuropsychiatric fluctuations in Parkinson's disease

  This study is testing a new questionnaire to see if it can reliably measure mood and behavior changes in people with Parkinson's disease.

  Recruiting University Hospital, Grenoble · Grenoble · NCT06701955

• Using deep rTMS to improve memory in Alzheimer's Disease

  This study is testing if a new brain treatment called deep rTMS can help improve memory in people with mild to moderate Alzheimer's Disease.

  Recruiting Phase 1/2 University of California, Los Angeles · Los Angeles, California · NCT06597942

• Using deep rTMS to improve memory in Alzheimer's Disease

  This study is testing if a new brain treatment called deep rTMS can help improve memory in people with mild to moderate Alzheimer's Disease.

  Recruiting Phase 1/2 University of California, Los Angeles · Los Angeles, California · NCT06597942

• Using deep rTMS to improve memory in Alzheimer's Disease

  This study is testing if a new brain treatment called deep rTMS can help improve memory in people with mild to moderate Alzheimer's Disease.

  Recruiting Phase 1/2 University of California, Los Angeles · Los Angeles, California · NCT06597942

• A platform for collecting health data on ME/CFS and Long Covid

  This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.

  Recruiting Brain Inflammation Collaborative · Delafield, Wisconsin · NCT04806620

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

NIH-funded research (newest 40 of 3533)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding CAG repeat instability in Huntington’s disease

  A Huntington’s disease study explores why the CAG repeat in the HTT gene becomes unstable and leads to earlier disease, aiming to uncover factors that influence when and how the disease starts.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11630975

• Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model

  Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.

  NIH research Nathan S. Kline Institute for Psych Res · Orangeburg, United States · NIH-11627965

• Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients

  A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11627145

• Non-invasive tears biomarker for early Alzheimer's in LMICs

  A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11623923

• Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s

  A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11622616

• Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health

  Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11622615

• Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues

  Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11619072

• Selective Targeting of Nurr1 for Alzheimer’s Disease

  A small study tests new brain-targeted compounds to help people with Alzheimer’s by reducing inflammation and protecting brain cells.

  NIH research Saint Louis University · Saint Louis, United States · NIH-11618618

• Thalamic sleep circuit changes in Alzheimer's disease

  Aims to understand how sleep-related brain activity in a key sleep regulator called the TRN affects Alzheimer’s progression and whether boosting TRN function could slow symptoms.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11617739

• How COVID-19 infection and genes may influence memory and dementia risk

  This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11617103

• ApoE and Reelin interactions in Alzheimer’s disease

  A researcher is studying how the ApoE ε4 protein interacts with Reelin in the brains of people at risk for or living with Alzheimer’s disease to understand why some people develop the disease.

  NIH research Rensselaer Polytechnic Institute · Troy, United States · NIH-11616963

• Negotiation training to help Alzheimer’s caregivers communicate with care teams

  A program called NegotiAge helps families caring for people with Alzheimer’s disease learn better negotiation skills to talk with doctors, insurers, and other caregivers.

  NIH research Northwestern University · Chicago, United States · NIH-11615642

• Gut-brain clues in Parkinson’s disease: supplement to a large registry

  A plant-wide supplement to an NIH program will enroll people with Parkinson’s, with and without GI symptoms, plus healthy controls, to study how gut function, brain signals, and sleep rhythms relate to Parkinson’s symptoms.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11612995

• Alzheimer’s disease and related brain changes linked to chemicals in the body

  This NIH grant supports a patient-centered effort to map how environmental exposures and body chemistry relate to Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609306

• Understanding how everyday exposures affect Alzheimer's disease progression

  A national research effort is studying how environmental exposures, gut health, diet, and metabolism relate to Alzheimer's and related dementias to identify new ways to diagnose and treat these conditions.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609305

• How environment, gut health, and metabolism affect Alzheimer’s disease

  This grant looks at how environmental exposures, gut microbes, diet, and metabolism influence Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11609304

• Social media support for Alzheimer's caregivers powered by AI chat help

  A caregiver-focused program for families of people with Alzheimer's and related dementias uses an AI-enhanced social media approach to provide daily supportive messages and online discussions.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11606532

• Lipids and brain aging in Alzheimer's disease

  Aims to understand how lipids in the body relate to aging of the brain and Alzheimer's disease by studying blood and brain-related lipid patterns.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11606401

• Metabolic clues from lipids in aging and Alzheimer's disease

  A lipid-focused research effort is exploring how fat-related molecules influence brain aging and Alzheimer's disease to uncover new ideas for care.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11606400

• Non-drug ways and gene therapy to boost deep sleep brain cleaning in Alzheimer's models

  This project tests three patient-friendly ideas to boost slow-wave brain activity in models of Alzheimer's disease, aiming to improve brain cleaning, reduce amyloid buildup, and boost memory-like tasks.

  NIH research Boston VA Research Institute, INC. · Boston, United States · NIH-11606008

• Understanding how chemical exposures affect Alzheimer's disease progression

  This project studies how environmental chemicals and other biological factors influence brain health and the course of Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11605998

• Cellular aging in Alzheimer's disease: finding senescent cells and their patterns

  Researchers will study whether aging-like cells called senescent cells appear in the brains of people with Alzheimer's disease and what their patterns mean for disease progression.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11605840

• P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data

  Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.

  NIH research Emory University · Atlanta, United States · NIH-11604418

• P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data

  Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.

  NIH research Emory University · Atlanta, United States · NIH-11604417

• Global picture of dementia risk and memory loss across the world

  A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.

  NIH research University of New South Wales · Sydney, Australia · NIH-11603263

• Understanding how Alzheimer's progresses over time using sparse brain scans and blood markers

  This grant aims to map the progression timeline of Alzheimer's disease using limited, real-world brain imaging and blood data to identify biomarkers and critical treatment windows.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11603148

• TargetAD: A network approach to repurpose drugs for Alzheimer's disease

  A research project is building a big, interconnected map of biological data to find existing drugs that could help people with Alzheimer’s disease.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11600904

• LEAD Africa: advancing Alzheimer’s research across Africa

  A new project aims to build Alzheimer’s disease research capabilities in Africa to improve understanding and care for people with dementia.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11599552

• Leading AD and related dementias research in Africa

  A multi-country effort aims to build Africa’s capacity to study Alzheimer’s disease and related dementias using scalable, low-cost methods.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11599551

• Alzheimer’s disease research collaboration in Africa to build precision medicine resources

  A multi-country project in Africa and the U.S. aims to create accessible, scalable ways to study Alzheimer’s disease and related dementias using new data and local infrastructure.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11599550

• Neutrophils and blood flow in vascular dementia and Alzheimer’s disease

  Researchers are studying how immune cells called neutrophils affect blood flow and brain inflammation in aging people with VCID and Alzheimer’s disease.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11597294

• Digital biomarkers for Alzheimer’s disease using voice and AI

  Aims to see if voice and language patterns can indicate Alzheimer’s disease before symptoms show up, using existing cohort data and new audio tests.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11597081

• NGF Metabolism as a biomarker for cognitive decline in familial Alzheimer's disease

  Researchers are studying whether patterns in nerve growth factor pathways in blood and CSF can signal early, preclinical stages of Alzheimer's in people with genetic risk.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11597025

• NGF metabolism as an early biomarker for cognitive decline in familial Alzheimer's disease

  This project tests whether NGF pathway proteins in blood and CSF can signal early, preclinical changes in people with familial Alzheimer’s disease.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11597016

• Genetic clues to Alzheimer's disease in Jewish and Arab communities

  This grant studies how genes influence Alzheimer's risk in Jews from the Middle East–North Africa and related groups to uncover variants that may affect disease in diverse populations.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11596649

• Genetic clues to Alzheimer's in Jewish and Arab communities

  This project looks for genetic factors linked to Alzheimer’s disease in Jews from Israel and Arabs living in the region to understand why some people are at higher risk.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11596648

• Genetic clues for Alzheimer’s in Jewish and Arab communities

  Researchers will study genetic factors linked to Alzheimer’s disease in Jewish and Arab populations to uncover variants that may influence risk.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11596647

• Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms

  A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11596497

• Scaling up pangenome graphs to study complex genetic changes in Alzheimer's disease

  A research project at Yale aims to improve how we map big genetic variations to understand Alzheimer’s disease.

  NIH research Yale University · New Haven, United States · NIH-11596496

• Metabolic clues from lipids to understand aging and Alzheimer’s disease

  This grant studies how lipids in the body relate to aging of the brain and the risk and progression of Alzheimer’s disease and related dementias.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11596450

Related topics

Quick answers

How many s Disease clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (15 trials), China (5 trials), France (2 trials), Poland (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 3, Phase 2: 2, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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