Understanding motivation in Parkinson's patients using neurophysiology
Understanding Motivation in Parkinson's Patients Through Neurophysiology
This study is testing how a brain device affects motivation and decision-making in people with Parkinson's disease while they do tasks that involve rewards.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT05065151 on ClinicalTrials.gov |
What this trial studies
This study investigates how motivation and decision-making are influenced in patients with Parkinson's disease through the use of Medtronic's Percept deep brain stimulation (DBS) device. Participants will engage in reward-based decision-making tasks while their neural activity is recorded, both in clinical and home settings. The study aims to assess the effects of DBS on motivation by comparing outcomes under different stimulation conditions, while participants continue their regular dopaminergic medications. The findings could provide insights into non-motor symptoms of Parkinson's and inform future adaptive DBS algorithms.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with Parkinson's disease or dystonia who have a Medtronic Percept or RC+S DBS device implanted.
Not a fit: Patients with severe cognitive impairments or those with a MOCA score below 20 may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of motivation in Parkinson's patients and lead to improved treatment strategies for managing non-motor symptoms.
How similar studies have performed: While there have been studies on DBS and motivation, this specific approach combining neurophysiology with behavioral tasks is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Has Parkinson's Disease or Dystonia * Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN * Has DBS device implanted either bilaterally or unilaterally * Male or female * More than 1 month post-DBS surgery Exclusion Criteria: * Severe cognitive impairments * Has MOCA score below 20 * Pregnancy * Age less than 18 years old
Where this trial is running
San Francisco, California
- University of California San Francisco — San Francisco, California, United States (Recruiting)
Study contacts
- Principal investigator: Simon J Little, MBBS, PhD — University of California, San Francisco
- Study coordinator: Sarah Wang, PhD
- Email: Sarah.Wang@ucsf.edu
- Phone: 415-353-7885
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.