Deep Brain Stimulation for Chronic Low Back Pain

Who could benefit from this research

What this research studies

This project uses a next-generation brain implant to modulate networks in the brain that process pain’s emotional and cognitive components, with a focus on the affective pathway that can amplify pain. Researchers will implant a directional DBS device and steer current to engage specific brain circuits implicated in chronic low back pain. The goal is to see if targeted brain stimulation can reduce pain and improve daily function in patients whose pain has not responded to standard care. The study will monitor safety, symptom changes, and potential biomarkers that might predict who benefits most. Participation will involve surgical implantation, follow-up visits, imaging, and regular assessments over several years.

Why it matters

Where this research is happening

• University of California Los Angeles
  Los Angeles, United States Active

Researchers

• Principal investigator: Bari, Ausaf — University of California Los Angeles
• Study coordinator: Bari, Ausaf

Related research

Other NIH-funded projects on the same topics.

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  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10221068

• Ketamine-assisted care plan to help Veterans with chronic back pain and depression

  A program for Veterans with chronic low back pain and depression that uses ketamine infusions followed by a brief narrative therapy to sustain relief from pain and mood improvement.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11533116

• Savoring Meditation for Chronic Low Back Pain patients

  A study tests a brief mindfulness-based practice called Savoring Meditation to help people with chronic low back pain feel better emotionally and manage pain in daily life.

  NIH research University of Virginia · Charlottesville, United States · NIH-11465428

• Chronic Low Back Pain in Older Adults and Hip Impairments

  A study to help older adults with chronic low back pain, by looking at how hip problems affect their pain and function and testing tailored non-drug treatments.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11447991

• Mechanical signs from the spine’s discs that predict when back pain becomes long-lasting

  A Duke study aims to use new imaging and personal factors to see if the mechanical health of spinal discs can predict when acute low back pain becomes chronic.

  NIH research Duke University · Durham, United States · NIH-11446556

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.