Scalp EEG mapping of DBS-induced electric fields
EEG Measurements to Capture DBS-induced Electric Potentials
Universitätsklinikum Hamburg-Eppendorf · NCT07115394
This will test whether very high–sampling-rate EEG can record the electric fields produced by DBS in people with Parkinson's disease or related movement disorders who already have implants.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 35 Years to 85 Years |
| Sex | All |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf (other) |
| Locations | 1 site (Hamburg) |
| Trial ID | NCT07115394 on ClinicalTrials.gov |
What this trial studies
Participants who are at least three months post-DBS implantation will have scalp EEG recorded at very high sampling rates (>100 kHz) while their DBS device is operated to capture the tiny, fast electrical potentials induced at the scalp. The recorded signals will be compared with and used to calibrate computer simulations of the DBS electric field. The protocol is observational and does not change clinical DBS settings beyond routine use. The work is led by the University Medical Center Hamburg-Eppendorf in collaboration with the University of Twente.
Who should consider this trial
Good fit: Adults aged 35–85 with Parkinson's disease, essential tremor, or dystonia who are more than three months after DBS surgery and can give written informed consent are eligible.
Not a fit: People without implanted DBS devices or those within three months of DBS surgery are not expected to benefit from this protocol.
Why it matters
Potential benefit: If successful, this could make DBS electric-field models more accurate and improve how clinicians plan and program stimulation.
How similar studies have performed: Previous EEG and modeling work has suggested scalp signals can reflect DBS effects, but using very high (>100 kHz) sampling to directly validate and calibrate field simulations is a relatively novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Provision of written informed consent by the patient * Age 35 - 85 * patient groups: Parkinson's disease, essential tremor, dystonia * \>3 months after surgery for DBS Exclusion Criteria: none.
Where this trial is running
Hamburg
- University Medical Center Hamburg-Eppendorf — Hamburg, Germany (RECRUITING)
Study contacts
- Study coordinator: Bettina C. Schwab, PhD
- Email: b.schwab@uke.de
- Phone: +49 40 7410 26907
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Deep Brain Stimulation, Parkinson', s Disease, deep brain stimulation, EEG, electric potential