Understanding how certain proteins affect lens clarity and cataract formation
Official title: Role of the S100 Family of Proteins in Lens Physiology and Cataract
Funded at Duke University · NIH-10893923 · Data updated 2026-11-12
This study is looking at how certain proteins in the eye help keep the lens clear and strong, which is important for good vision, and it hopes to find new ways to prevent or treat cataracts that could help people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $402,500 |
| NIH project number | 5R01EY034450-02 |
| Project ID | NIH-10893923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing cataracts or those with early signs of lens opacity.
✕Less likely to help
Patients with cataracts that are already advanced or those who do not have any lens-related issues may not benefit from this research.
What this research studies
This research investigates the role of the S100 family of proteins in maintaining the clarity and mechanical properties of the ocular lens, which is essential for proper vision. By studying how these proteins interact with lens cells and contribute to cataract formation, the research aims to uncover the molecular pathways involved in lens physiology. The approach includes using mouse models to observe the effects of specific S100 proteins on lens transparency and structure. Patients may benefit from insights that could lead to new treatments or preventive strategies for cataracts.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cataracts, potentially reducing vision impairment in patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of calcium-binding proteins in various cellular functions, suggesting potential for success in this area as well.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Rao, P Vasantha — Duke University
- Study coordinator: Rao, P Vasantha
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Role of S100 Proteins in the Eye Lens and Cataract
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.