Why some people get age-related cataracts and how to predict who is at risk
The Role of Genetic and Non-Genetic Factors and Causal Mechanisms Underlying Cataract Susceptibility For Risk Prediction
['FUNDING_R01'] · KAISER FOUNDATION RESEARCH INSTITUTE · NIH-11136900
This project looks for genetic differences and lifestyle factors that explain why some adults develop age-related cataracts to improve risk prediction.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | KAISER FOUNDATION RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (Oakland, UNITED STATES) |
| Trial ID | NIH-11136900 on ClinicalTrials.gov |
What this research studies
This work builds on a large multiethnic genetic analysis that found 55 gene regions linked to cataract. Researchers will study how those genes function in the eye lens, examine whether the genetic signals change gene regulation across tissues, and explore connections between cataracts and traits like glaucoma, myopia, smoking, and BMI. The team will combine human genetic data, tissue-expression resources, and lab follow-up experiments to identify causal mechanisms. The ultimate aim is to merge genetic and non-genetic information to create better tools for predicting who may develop cataracts.
Who could benefit from this research
Good fit: Ideal candidates would be middle-aged or older adults, especially from diverse ethnic backgrounds or those with a family history of cataract.
Not a fit: People with congenital or pediatric cataracts or eye problems not related to age-related lens changes are unlikely to benefit from these findings.
Why it matters
Potential benefit: If successful, this could help identify people at higher risk for cataracts earlier and suggest ways to prevent or delay vision loss.
How similar studies have performed: Previous large genetic studies have identified many cataract-associated regions, but converting those findings into prevention or treatment strategies remains largely unproven.
Where this research is happening
Oakland, UNITED STATES
- KAISER FOUNDATION RESEARCH INSTITUTE — Oakland, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOQUET, HELENE — KAISER FOUNDATION RESEARCH INSTITUTE
- Study coordinator: CHOQUET, HELENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.