Exploring dry eye disease patterns after cataract surgery
Ocular Surface and Corneal Morphological Changes After the Cataract Surgery and Associations With Inflammatory Biomarkers
This study looks at how cataract surgery affects dry eye symptoms in patients aged 50 to 90 and tests if using artificial tears helps improve their comfort over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 50 Years to 90 Years |
| Sex | All |
| Sponsor | Lithuanian University of Health Sciences Academic / other |
| Locations | 1 site (Kaunas) |
| Trial ID | NCT06298890 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the patterns of dry eye disease (DED) following cataract surgery, focusing on ocular surface changes, corneal morphology, and patients' subjective assessments of DED. It aims to correlate these factors with ocular surface inflammation and pain biomarkers, while also evaluating the effectiveness of artificial tears for lubrication during long-term follow-up. The study involves cataract patients aged 50 to 90 who have undergone uncomplicated phacoemulsification by a single experienced surgeon.
Who should consider this trial
Good fit: Ideal candidates are cataract patients aged 50 to 90 without prior ocular surface diseases or surgeries.
Not a fit: Patients with severe dry eye disease, glaucoma, diabetes, or other systemic conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of dry eye disease post-cataract surgery and improve management strategies for affected patients.
How similar studies have performed: While there have been studies on dry eye disease, this specific approach focusing on post-cataract surgery patterns is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cataract patients from 50 to 90 years old who underwent uncomplicated phacoemulsification performed by one (and same) experienced surgeon. * Patients with no underlying ocular surface diseases (keratitis, keratoconjunctivitis and others). * Patients who previously did not undergo any ophthalmic surgery. Exclusion Criteria: * Patient expressed his wish to not participate in the study or discontinue it when already enrolled. * Severe dry eye disease diagnosed with OSDI/DEQ-5 and at least one of the following tests: TBUT less than 10 seconds, tear osmolarity higher than 308 mOsm/l or positive corneal staining. * Glaucoma. * Diabetes mellitus. * Systemic connective tissue disease, autoimmune disease. * Neurologic conditions including stroke, Bell's palsy, Parkinson's, trigeminal nerve dysfunction. * Patients who underwent refractive surgery (LASIK or PRK). * Contact lens users. * One or more of the following concomitant medications: psychiatric medicines, antihistamines and/or hormonal replacement. * Patients who are already regularly using topical drops or ointments.
Where this trial is running
Kaunas
- Lithuanian University of Health Sciences — Kaunas, Lithuania (Recruiting)
Study contacts
- Study coordinator: Reda Zemaitiene
- Email: reda.zemaitiene@lsmuni.lt
- Phone: +37037327064
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.