Exploring dry eye disease patterns after cataract surgery
Official title: Ocular Surface and Corneal Morphological Changes After the Cataract Surgery and Associations With Inflammatory Biomarkers
Run by Lithuanian University of Health Sciences · NCT06298890 · Data updated 2026-11-12
This study looks at how cataract surgery affects dry eye symptoms in patients aged 50 to 90 and tests if using artificial tears helps improve their comfort over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years to 90 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Lithuanian University of Health Sciences Academic / other |
| Locations | 1 site (Kaunas) |
| Status | Recruiting |
| Started | March 2024 |
| Main results expected | May 2026 |
| Study ends | September 2027 |
| Registry record updated | March 7, 2024 |
| Trial ID | NCT06298890 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are cataract patients aged 50 to 90 without prior ocular surface diseases or surgeries.
✕Probably not a fit
Patients with severe dry eye disease, glaucoma, diabetes, or other systemic conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the patterns of dry eye disease (DED) following cataract surgery, focusing on ocular surface changes, corneal morphology, and patients' subjective assessments of DED. It aims to correlate these factors with ocular surface inflammation and pain biomarkers, while also evaluating the effectiveness of artificial tears for lubrication during long-term follow-up. The study involves cataract patients aged 50 to 90 who have undergone uncomplicated phacoemulsification by a single experienced surgeon.
Why it matters
Potential benefit: If successful, this study could enhance understanding of dry eye disease post-cataract surgery and improve management strategies for affected patients.
How similar studies have gone: While there have been studies on dry eye disease, this specific approach focusing on post-cataract surgery patterns is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cataract patients from 50 to 90 years old who underwent uncomplicated phacoemulsification performed by one (and same) experienced surgeon. * Patients with no underlying ocular surface diseases (keratitis, keratoconjunctivitis and others). * Patients who previously did not undergo any ophthalmic surgery. Exclusion Criteria: * Patient expressed his wish to not participate in the study or discontinue it when already enrolled. * Severe dry eye disease diagnosed with OSDI/DEQ-5 and at least one of the following tests: TBUT less than 10 seconds, tear osmolarity higher than 308 mOsm/l or positive corneal staining. * Glaucoma. * Diabetes mellitus. * Systemic connective tissue disease, autoimmune disease. * Neurologic conditions including stroke, Bell's palsy, Parkinson's, trigeminal nerve dysfunction. * Patients who underwent refractive surgery (LASIK or PRK). * Contact lens users. * One or more of the following concomitant medications: psychiatric medicines, antihistamines and/or hormonal replacement. * Patients who are already regularly using topical drops or ointments.
Where it's running
-
Lithuanian University of Health Sciences
Kaunas, Lithuania Recruiting
Study contacts
- Study coordinator: Reda Zemaitiene
- Email: reda.zemaitiene@lsmuni.lt
- Phone: +37037327064
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.