Using advanced imaging technology during eye surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to develop and implement microscope integrated optical coherence tomography (MIOCT) to provide real-time volumetric imaging during intraocular surgeries. By enhancing surgical visualization, the technology seeks to improve outcomes for patients undergoing procedures for various retinal diseases, including macular holes and diabetic retinopathy. The study will involve both healthy controls and patients requiring vitreoretinal or anterior segment surgeries, allowing for a comprehensive evaluation of the technology's effectiveness. The goal is to overcome current limitations in surgical practice and enable new microsurgical techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Healthy controls: Healthy eyes without known disease: refractive error including myopia and non-significant cataract is allowed. For selected testing pseudophakia is allowed.
2. Surgeons as research subjects: Adult (≥18 years old)
3. Surgical patients (vitreoretinal surgery): Patients undergoing examination under anesthesia or surgery for vitreoretinal diseases
4. Surgical patients (anterior segment surgery-glaucoma, ocular surface or strabismus requiring extraocular muscle surgery): Include both adults and children. Patient undergoing primary, elective minimally invasive glaucoma surgery, ocular surface surgery, or strabismus surgery.

Exclusion Criteria:

1. Healthy controls: Any ocular disease that restricts the ability to perform OCT scanning. Conflict of interest with investigators/study personnel, e.g. a student in the lab of an investigator.
2. Surgeons as research subjects: no specific exclusion criteria.
3. Surgical patients (vitreoretinal surgery): Neonates (\< 4 weeks of age) and patients with any ocular disease that restricts the ability to perform OCT scanning.
4. Surgical patients (anterior segment surgery-corneal and cataract diseases): Pediatric patients: The cornea and cataract surgery studies will be restricted to adults (≥ 18 years). Children do not have cataract surgery typically by residents and therefore would not fit our study design. Similarly pediatric corneal transplants are very rare.

Where it's running

• Duke University Eye Center
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Cynthia A Toth, MD — Duke University
• Study coordinator: Neeru Sarin, MBBS
• Email: neeru.sarin@duke.edu
• Phone: 919-668-5341

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing surgery times for UNITY® VCS and CONSTELLATION® Vision System

  This study will see if the UNITY® VCS or the CONSTELLATION® Vision System leads to shorter combined cataract and vitrectomy (phacovitrectomy) surgery times for adults planned for 25‑gauge procedures.

  Recruiting Alcon Research · Manchester · NCT07228091

• Tracking retinal changes over two years in people with moderate to early proliferative diabetic retinopathy

  This project will try to find imaging, functional, and blood markers that show whether retinopathy is getting worse over two years in people with type 2 diabetes and moderate-to-mildly advanced disease.

  Recruiting Association for Innovation and Biomedical Research on Light and Image · Coimbra · NCT07458516

• Vision screening in general practice to catch preventable sight loss in people over 70

  This project will test a GP-based vision-screening program for people aged 70 and older with at least one chronic condition to find sight problems early.

  Recruiting at 2 sites University of Copenhagen · Copenhagen, Capital Region and 1 other locations · NCT07015034

• Implanting functional intraocular lenses in patients with epiretinal membrane

  This study is testing whether a special type of eye lens can improve vision better than a standard lens for cataract patients with a specific eye condition.

  Recruiting at 2 sites Eye & ENT Hospital of Fudan University · Shanghai, Shanghai Municipality and 1 other locations · NCT06719739

• Exploring new imaging techniques for eye diseases

  This study is testing a new eye imaging technique to better understand diseases like diabetic retinopathy and macular degeneration in order to improve treatment for patients.

  Recruiting Johannes Kepler University of Linz · Linz, Upper Austria · NCT06074731

• Biorepository for studying retinal diseases

  This study is collecting health information and samples from people with and without eye diseases to see how these conditions develop and respond to treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01496625

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.