tRF-31 and HIPK2 in age-related cataract: a look at eye tissue and surgery outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study will collect anterior lens capsule tissue from adults with age-related cataract undergoing standard phacoemulsification with IOL. Researchers will measure tRF-31 expression and HIPK2 levels and examine their relationship to Emery-Little cataract grade. Preoperative eye tests, including corneal endothelial cell counts, will be performed, and oxidative stress in the anterior segment will be considered for potential effects on the corneal endothelium. The work is purely observational and uses tissue already removed during routine surgery. No experimental interventions beyond standard care are involved.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients older than 18 years. Clinically diagnosed with age-related cataract (ARC) and have clear surgical indications for routine phacoemulsification combined with intraocular lens (IOL) implantation. Scheduled to undergo cataract extraction and intraocular lens implantation. Completed routine preoperative corneal endothelial specular microscopy, providing objective data including cell density, coefficient of variation of cell area, and the proportion of hexagonal cells. Provided signed written informed consent.

Exclusion Criteria:

History of ocular trauma, glaucoma, episodes of active uveitis, or previous intraocular surgery. Presence of severe systemic diseases rendering the patient unsuitable for surgery. Poor patient compliance or coexisting psychiatric disorders. Severe systemic metabolic syndromes (e.g., diabetes). Diagnosis of high myopia. Current participation in other clinical trials or likelihood of being lost to follow-up.

Where it's running

• Second Affiliated Hospital of Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Yueyang Zhong
• Email: yyzbzhong@zju.edu.cn
• Phone: +86+ 18868125901

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.