Corneal Biomechanics and Surgical Astigmatism after Cataract Surgery in Pseudoexfoliation
Official title: Influence of Corneal Biomechanics on Surgically Induced Astigmatism After Cataract Surgery in Patients With Pseudoexfoliation Syndrome
Run by Eye Clinic Medic Zuljan Jukic · NCT07722247 · Data updated 2026-11-12
This study tests how the cornea's biomechanical properties before cataract surgery relate to the amount of blinking surgically induced astigmatism, comparing people with pseudoexfoliation to those without.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years to 85 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Eye Clinic Medic Zuljan Jukic Academic / other |
| Locations | 1 site (Split, Splitsko-dalmatinska County) |
| Status | Recruiting |
| Started | July 20, 2026 |
| Main results expected | October 2026 |
| Study ends | October 2026 |
| Registry record updated | August 18, 2026 |
| Trial ID | NCT07722247 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 50–85 with age-related cataract scheduled for standard phacoemulsification, with or without pseudoexfoliation syndrome, who can consent and attend follow-up visits.
✕Probably not a fit
Patients without measurable corneal biomechanical differences or those not undergoing phacoemulsification may not see a direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, single-center observational study will measure corneal hysteresis (CH), corneal resistance factor (CRF), and corneal astigmatism in adults undergoing standard phacoemulsification cataract surgery. Participants will be divided into two groups based on the presence or absence of pseudoexfoliation syndrome and followed before and after surgery. Measurements will occur preoperatively and on postoperative day 1, day 7, and day 30 to analyze correlations between biomechanical properties and surgically induced astigmatism. The primary aim is to determine whether CH and CRF correlate with changes in astigmatism and whether these relationships differ between the PEX and non-PEX groups.
Why it matters
Potential benefit: If successful, the findings could help anticipate which patients might experience greater astigmatic changes after cataract surgery based on corneal biomechanics.
How similar studies have gone: There is limited published work specifically linking preoperative corneal biomechanics to Surgically Induced Astigmatism in pseudoexfoliation; some related studies suggest biomechanical properties influence corneal responses after surgery.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 50-85 years * Age-related cataract scheduled for standard phacoemulsification cataract surgery with intraocular lens implantation * Presence of pseudoexfoliation syndrome (PEX group) or absence of pseudoexfoliation syndrome (control group) * Ability to provide written informed consent * Willingness to attend all scheduled postoperative follow-up visits Exclusion Criteria: * Previous ocular surgery in the study eye * Corneal diseases or abnormalities that may affect corneal biomechanical measurements or keratometry * Glaucoma and ocular hypertension * Ocular trauma or active ocular inflammation
Where it's running
-
Eye Clinic Medic Jukic
Split, Splitsko-dalmatinska County, Croatia Recruiting
Study contacts
- Study coordinator: Kata Culina, MD, PhD
- Email: kculina@yahoo.com
- Phone: +38598615556
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.