Preventing Clouding After Cataract Surgery
Official title: Lens capsule and secondary cataract
Funded at University of Colorado Denver · NIH-11138695 · Data updated 2026-11-12
This research looks at why some people get cloudy vision again after cataract surgery, hoping to find ways to stop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 30, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $362,236 |
| NIH project number | 5R01EY033915-04 |
| Project ID | NIH-11138695 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is relevant to adults who have had or are considering cataract surgery and are at risk for secondary cataracts.
✕Less likely to help
Patients who have not had cataract surgery or are not at risk for posterior capsular opacification would not directly benefit from this specific research.
What this research studies
After cataract surgery, some people experience a return of cloudy vision, called posterior capsular opacification (PCO), which requires another laser procedure. This happens when certain cells left behind after surgery grow and create new tissue that clouds the lens capsule. Our work explores how specific substances in the aged lens, called Advanced Glycation End Products (AGEs), might trigger these cells to cause PCO. We believe that by understanding this process, we can develop new ways to prevent this common complication, potentially reducing the need for follow-up surgeries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or methods to prevent secondary cataracts, reducing the need for additional laser procedures after initial cataract surgery.
How similar studies have gone: This project builds upon preliminary findings and proposes a novel hypothesis regarding the role of AGEs and senescent cells in secondary cataract formation.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Nagaraj, Ram H — University of Colorado Denver
- Study coordinator: Nagaraj, Ram H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.