Analyzing eye fluid and tissues to find glaucoma-related markers in people with cataracts.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect small samples of aqueous humor (~100 µL) and routinely removed ocular tissues during standard cataract surgery, with additional scleral tissue obtained in the glaucoma group. Samples will be analyzed by proteomics (LC-MS/MS) and elemental profiling (ICP-MS, with LA-ICP-MS mapping for selected samples) and interpreted using bioinformatic methods. Participants will receive routine clinical exams including intraocular pressure measurement, optic nerve evaluation, OCT retinal nerve fiber layer analysis, and Humphrey visual fields. The aim is to identify molecular and chemical patterns associated with primary open-angle glaucoma that could serve as diagnostic or prognostic biomarkers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation).
* Ability to provide written informed consent.
* For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure.
* For control arm: cataract without glaucoma and without other significant ocular pathology.

Exclusion Criteria:

* Age \< 18 years.
* Pregnancy or breastfeeding.
* Advanced visual impairment in the study eye (visual aquity worse than counting fingers).
* Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma).
* History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery.
* Active or previous uveitis.
* Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm).
* Inability to comply with study procedures or follow-up visits.

Where it's running

• Military Institute of Medicine - National Research Institute
  Warsaw, Poland Recruiting
• University of Warsaw
  Warsaw, Poland Recruiting

Study contacts

• Principal investigator: Marek Rękas, MD, PhD — Military Institute od Medicine National Research Institute
• Study coordinator: Marek Rękas, MD, PhD
• Email: mrekas@wim.mil.pl
• Phone: 0048665 707 626

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.