Understanding genetic and non-genetic factors that contribute to cataract risk
Official title: The Role of Genetic and Non-Genetic Factors and Causal Mechanisms Underlying Cataract Susceptibility For Risk Prediction
Funded at Kaiser Foundation Research Institute · NIH-10875664 · Data updated 2026-11-12
This study is looking at how both genes and other health factors can increase the chances of getting age-related cataracts, which can lead to blindness, so we can find out who might be at risk and how to help prevent them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $404,695 |
| NIH project number | 5R01EY033010-03 |
| Project ID | NIH-10875664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who may be at risk for developing cataracts due to genetic or lifestyle factors.
✕Less likely to help
Patients who are not at risk for cataracts or who have already undergone cataract surgery may not benefit from this research.
What this research studies
This research investigates the various genetic and non-genetic factors that contribute to the risk of developing age-related cataracts, a leading cause of blindness. By conducting a large-scale analysis of genetic data, the study aims to identify specific genes associated with cataract susceptibility and explore how these genes function in the eye. The research also examines the relationship between cataracts and other health conditions, such as glaucoma and obesity, to better understand the broader implications of cataract development. Ultimately, the goal is to identify at-risk individuals and develop effective prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved risk prediction and prevention strategies for cataracts, potentially reducing the incidence of blindness.
How similar studies have gone: Previous research has successfully identified genetic factors associated with cataract risk, suggesting that this approach has potential for further breakthroughs.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Choquet, Helene — Kaiser Foundation Research Institute
- Study coordinator: Choquet, Helene
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.