Using a capsular tension ring to keep the lens implant centered in people with retinitis pigmentosa who need cataract surgery
Official title: Effect of Capsular Tension Ring Implantation on Postoperative IOL Position in Retinitis Pigmentosa Patients With Cataract: a Multi-center, Randomized, Self-controlled Study
Run by Zhongshan Ophthalmic Center, Sun Yat-sen University · NCT07126470 · Data updated 2026-11-12
This trial will try adding a capsular tension ring to one eye of adults with retinitis pigmentosa undergoing cataract surgery to see if it keeps the implanted lens more centered and reduces vision problems compared with the other eye.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 88 (estimated) |
| Sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University Academic / other |
| Locations | 3 sites (Guangzhou, Guangdong and 2 other locations) |
| Status | Recruiting |
| Started | August 25, 2025 |
| Main results expected | August 2027 |
| Study ends | August 2027 |
| Registry record updated | April 23, 2026 |
| Trial ID | NCT07126470 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) with a clinical diagnosis of retinitis pigmentosa and bilateral cataracts appropriate for IOL implantation who can give informed consent and attend scheduled follow-up visits are the intended participants.
✕Probably not a fit
Patients with prior intraocular surgery, severe zonular dialysis (>90%) or lens dislocation, significant coexisting ocular disease (such as uveitis or pseudoexfoliation), or severe systemic illness are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Retinitis pigmentosa often causes zonular weakness and capsular changes that increase the risk of intraocular lens (IOL) tilt, decentration, and capsular contraction after cataract surgery. This self-controlled randomized trial will enroll 88 adults with bilateral cataracts and RP, implanting the same monofocal DCB00 IOL in both eyes but adding a capsular tension ring (CTR) to one randomly chosen eye while the fellow eye serves as the control. Outcomes including IOL decentration and tilt measured by anterior segment SS-OCT (CASIA2), visual acuity, and postoperative complications will be recorded at 1 week, 1 month, 3 months, 6 months, and 1 year. Intraindividual comparison aims to clarify whether CTR reduces lens malposition and related complications in this high-risk population.
Why it matters
Potential benefit: If successful, adding a CTR could keep the lens implant straighter and more stable after cataract surgery, potentially improving vision and reducing complication rates in people with RP.
How similar studies have gone: CTR use is established to stabilize the capsular bag in eyes with zonular weakness, but its specific benefit in retinitis pigmentosa remains controversial and has not been definitively proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Clinical diagnosis of retinitis pigmentosa (RP). * Bilateral cataract meeting the indications for IOL implantation. * Willingness to participate in the study and provision of signed informed consent. Exclusion Criteria: * History of intraocular surgery. * Severe zonular weakness (e.g., zonular dialysis \>90°, lens subluxation/dislocation) * Other ocular comorbidity: such as pseudoexfoliation syndrome, ocular trauma, corneal dystrophies, uveitis, etc. * Severe systemic diseases: such as severe hypertension, diabetes, heart disease, Alzheimer's, Parkinson, etc.
Where it's running
-
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting -
Shenzhen Eye Hospital
Shenzhen, Guangdong, China Not yet recruiting -
Wuhan Aier Eye Hospital
Wuhan, Hubei, China Not yet recruiting
Study contacts
- Principal investigator: Xuhua Tan, PhD — Zhongshan Ophthalmic Center, Sun Yat-sen University
- Study coordinator: Yuke Pan, Master
- Email: 1693156383@qq.com
- Phone: 8613060768121
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.