Effect of Dry Eye Treatment on Corneal Astigmatism Measurements

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center study recruits patients undergoing preoperative cataract evaluation and groups them by presence of dry eye disease. Participants have ocular surface assessments and corneal astigmatism measurements repeated with three devices (IOLMaster 700, Pentacam AXL, iTrace Prime) to compare inter-device agreement and repeatability. In those with dry eye, 0.3% sodium hyaluronate eye drops are given four times daily for two weeks, after which measurements are repeated to assess short-term effects on measurement consistency. The primary aim is to see if dry eye disease alters how accurately and reliably multiple devices record keratometric and total corneal astigmatism, including vector components.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with age-related cataract undergoing preoperative ocular examination.
* Ability to complete ocular surface evaluation, including the Ocular Surface
* Disease Index questionnaire, non-invasive tear film break-up time, tear meniscus height, Schirmer test, and ocular surface staining.
* Ability to complete repeated corneal astigmatism measurements using IOLMaster 700, Pentacam AXL, and iTrace Prime.
* Ability to maintain stable fixation during device measurements. Provision of written informed consent.

Exclusion Criteria:

* Previous ocular surgery or ocular trauma.
* Corneal degeneration, corneal dystrophy, or other corneal diseases that could affect corneal measurements.
* Active corneal or conjunctival infection.
* Uveitis.
* Use of any topical eye drops within 24 hours before examination.
* Use of antiglaucoma medications.
* Contact lens wear within 1 month before examination.
* Previous or ongoing treatment for dry eye disease.
* Poor fixation during device measurements.
* Poor-quality measurements from any study device

Where it's running

• Eye and ENT hospital of Fudan University
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Xuanqiao Lin, Doctor
• Email: 1532483480@qq.com
• Phone: +8615088920668

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.