Intranasal dexmedetomidine to stabilize blood pressure during cataract surgery in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3 interventional trial compares intranasal dexmedetomidine (1 mcg/kg ideal body weight, diluted to 1 mL and delivered with a mucosal atomization device, 0.5 mL per nostril) to matching intranasal saline given before peribulbar anesthesia for elective cataract surgery. A peribulbar block using lidocaine 2% and bupivacaine 0.5% is used for local anesthesia in all patients. The primary outcome is perioperative mean arterial pressure (MAP) with secondary outcomes including sedation quality and adverse events. Eligible participants are adults aged 65 or older with stage 2 hypertension and ASA physical status II or III.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged ≥65 years.
2. Patients who will have stage 2 hypertension as per ACC/AHA guidelines (Systolic BP \> 140 and Diastolic BP\> 90 mmHg)
3. Elective cataract surgery under local anesthesia.
4. American Society of Anesthesiologists (ASA) physical status II or III.

Exclusion Criteria:

1. Allergy or contraindication to dexmedetomidine.
2. Significant baseline bradycardia (\<50 bpm) or arrhythmias.
3. Use of sedative or anxiolytic medications.
4. History of severe hepatic, renal, or cerebrovascular diseases.

Where it's running

• Suez Canal University Hospitals
  Ismailia, Ismailia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Mohammad E Salama, MD
• Email: MohammadElhossieny88@med.suez.edu.eg
• Phone: +201016865861

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.