Understanding how a specific genetic change leads to age-related cataracts
Official title: Molecular Mechanism of αAN101D-Transgene-Induced Age-Related Cataract
Funded at University of Alabama at Birmingham · NIH-10597653 · Data updated 2026-11-12
This study is looking at how certain changes in eye proteins can lead to cataracts as we get older, using a special mouse model to help us understand what happens in our eyes, so we can find better ways to prevent or treat cataracts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $394,771 |
| NIH project number | 5R01EY031303-04 |
| Project ID | NIH-10597653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing early signs of cataracts or those with a family history of cataract development.
✕Less likely to help
Patients with cataracts caused by trauma or other non-age-related factors may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind the development of age-related cataracts, focusing on the aggregation of lens proteins called crystallins. Using a unique mouse model with a specific genetic mutation, the study aims to connect laboratory findings with real-life changes in the eye that lead to cataracts. By examining how the deamidation of crystallins affects their properties and contributes to lens opacity, the research seeks to uncover the underlying causes of cataract formation as people age.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for preventing or delaying cataract formation in aging populations.
How similar studies have gone: While there has been extensive research on crystallins and cataract formation, this specific approach using a genetic mouse model is relatively novel and aims to bridge gaps in existing knowledge.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Srivastava, Om Prakash — University of Alabama at Birmingham
- Study coordinator: Srivastava, Om Prakash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.