Identifying eye structure changes in children after cataract surgery to predict glaucoma risk
Official title: Identification of Anterior Segment Structural Biomarkers in Glaucoma Following Pediatric Cataract Using Ultrasound Biomicroscopy
Funded at University of Maryland Baltimore · NIH-10880646 · Data updated 2026-11-12
This study is looking at how certain features of the eye can help doctors figure out if kids who have had cataract surgery might be at risk for glaucoma, using special imaging technology to get a closer look at their eyes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $236,357 |
| NIH project number | 5K23EY032525-03 |
| Project ID | NIH-10880646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have undergone cataract surgery.
✕Less likely to help
Patients who have not had cataract surgery or are older than 11 years may not benefit from this research.
What this research studies
This research investigates how specific structural features of the eye can indicate the risk of developing glaucoma in children who have undergone cataract surgery. Using advanced imaging techniques called ultrasound biomicroscopy, the study aims to analyze the anterior segment of the eye to identify potential biomarkers for glaucoma. By understanding these structural changes, clinicians hope to provide personalized risk assessments and improve early diagnosis and treatment for affected children. The research is focused on enhancing care for pediatric patients with ophthalmic diseases.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of glaucoma in children who have had cataract surgery.
How similar studies have gone: Previous research has shown promise in using imaging techniques to identify risk factors for glaucoma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Alexander, Janet Leath — University of Maryland Baltimore
- Study coordinator: Alexander, Janet Leath
Related research
Other NIH-funded projects on the same topics.
-
IOP and CSF Pressure in Glaucoma Risk
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
-
Modulating deep brain activity with focused ultrasound for cocaine use disorder
A study will test whether targeting a deep brain region with focused ultrasound can alter brain signals related to craving in people with cocaine use disorder.
-
Dose-Dependent Brain Wire Modulation with Light Ultrasound in Deep White Matter
A small early study tests whether gentle, noninvasive ultrasound can change how deep brain white matter tracts work in healthy adults.
-
Ultrasound-guided brain circuit targets for treatment-resistant depression
This grant tests whether focused ultrasound can safely and reversibly adjust brain circuits linked to negative mood in people with treatment-resistant depression.
-
Ultrasound biomarkers to diagnose and predict treatment response for plantar heel pain
A study will test advanced ultrasound imaging to find biomarkers that help diagnose plantar heel pain and predict who will respond to targeted treatments.
-
Brain ultrasound and microcirculation to understand early brain development in HIV-exposed uninfected infants
We’re studying how brain ultrasound and blood flow patterns in newborns exposed to HIV and antiretroviral drugs (but not infected) relate to their early neurodevelopment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.