Combining endoscopic cyclophotocoagulation with cataract surgery for normal tension glaucoma
Official title: Endoscopic Cyclophotocoagulation in Normal Tension Glaucoma
Run by Helsinki University Central Hospital · NCT04651530 · Data updated 2026-11-12
This study is testing if adding a special eye treatment during cataract surgery can help people with normal tension glaucoma lower their eye pressure better than cataract surgery alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 55 Years to 100 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Helsinki University Central Hospital Academic / other |
| Locations | 1 site (Helsinki) |
| Status | Recruiting |
| Started | December 8, 2020 |
| Main results expected | December 1, 2025 |
| Study ends | December 1, 2026 |
| Registry record updated | December 22, 2020 |
| Trial ID | NCT04651530 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with stable normal tension glaucoma and clinically significant cataracts who are currently on medication.
✕Probably not a fit
Patients with secondary glaucoma or those who have had previous glaucoma surgeries are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of adding endoscopic cyclophotocoagulation (ECP) to cataract surgery in patients with normal tension glaucoma. Participants with stable glaucoma who require cataract surgery will be randomly assigned to receive either ECP during their cataract surgery or cataract surgery alone. The primary goal is to determine if the combination procedure results in lower intraocular pressure compared to cataract surgery by itself. The study aims to provide insights into improving treatment outcomes for patients with this specific type of glaucoma.
Why it matters
Potential benefit: If successful, this approach could lead to better management of intraocular pressure in patients with normal tension glaucoma undergoing cataract surgery.
How similar studies have gone: Other studies have shown promising results with similar surgical approaches, suggesting potential for success in this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Signed Informed Consent * Normal Tension Glaucoma with typical nerve fiber layer defects in red-free photographs and/or optical coherence tomography (OCT) and possible equivalent visual field defects, IOP never more than 21 mmHg, and open anterior chamber angle * Glaucoma stable with current medication assessed by a glaucoma specialist * Clinically significant cataract Exclusion Criteria: * Secondary Glaucoma e.g. due to previous injury or uveitis * Exfoliation syndrome * Pigment dispersion syndrome * Previous transscleral or endoscopic cyclophotocoagulation * Previous other glaucoma surgery * Cataract due to eye injury or congenital cataract * Zonular weakness due to Marfan syndrome or other * Previous retinal detachment * Previous intraocular surgery like vitrectomy and other retinal surgery * Wet age-related macular degeneration * Diabetic retonopathy * Previous corneal transplant or previous refractive surgery * Fuchs' dystrophy and other abnormalities compromising corneal clarity like scars * The patient does not want to participate in the study * The glaucoma progresses on current IOP * The patient does not speak Finnish, Swedish or English * Dementia * Only eye with vision worse than 20/200 or loss of central visual field
Where it's running
-
Helsinki University Hospital
Helsinki, Finland Recruiting
Study contacts
- Principal investigator: Mika Harju, MD, PhD — Helsinki University Central Hospital
- Study coordinator: Nina M Lindbohm, MD, PhD
- Email: nina.lindbohm@hus.fi
- Phone: +358505715668
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Rotational Stability of the Acunex Vario Toric
This study tests whether the Acunex Vario toric extended-depth-of-focus intraocular lens stays stable in rotation and effectively reduces astigmatism for people undergoing cataract surgery.
-
Anterior segment anatomy assessment with swept-source OCT in eye surgery patients
This study tests whether swept-source OCT can detail front-eye anatomy in patients undergoing anterior segment eye surgery.
-
MiLOOP-assisted cataract surgery for dense cataracts
In people with dense cataracts, this study tests whether using the miLOOP device during cataract surgery can protect corneal cells and reduce ultrasound energy, compared with standard surgery.
-
Visual adaptation and quality of life after different IOL implantation options
This study follows adults who have cataracts and receive bilateral multifocal or mixed IOLs to see how their vision and daily life improve over 6 months.
-
Corneal Biomechanics and Surgical Astigmatism after Cataract Surgery in Pseudoexfoliation
This study tests how the cornea's biomechanical properties before cataract surgery relate to the amount of blinking surgically induced astigmatism, comparing people with pseudoexfoliation to those without.
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Neuroplastic pain education and guided breathing during awake cataract surgery
This trial tests whether the STEIN Protocol, a non-drug approach with pain education, guided imagery, and paced breathing, helps adults having cataract surgery require less pain medicine and feel less anxious.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.