Visual adaptation and quality of life after different IOL implantation options
Official title: Evaluation of Visual Adaptation and Optical Performance in Patients With Bilateral Multifocal or Mix-and-Match Intraocular Lens Implantation: A Longitudinal Observational Study
Run by Sichuan Academy of Medical Sciences · NCT07740590 · Data updated 2026-11-12
This study follows adults who have cataracts and receive bilateral multifocal or mixed IOLs to see how their vision and daily life improve over 6 months.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 264 (estimated) |
| Sponsor | Sichuan Academy of Medical Sciences Academic / other |
| Locations | 1 site (Chengdu) |
| Status | Recruiting |
| Started | March 1, 2025 |
| Main results expected | October 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | July 31, 2026 |
| Trial ID | NCT07740590 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and older with age-related cataract, scheduled for bilateral IOL implantation, with low corneal astigmatism and good overall health who are willing to complete follow-up.
✕Probably not a fit
Individuals with ocular comorbidities affecting vision, prior ocular surgery, or complications during/after surgery may not experience the same benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study examines long-term visual adaptation, optical quality, and patient-reported outcomes after bilateral implantation of multifocal or mix-and-match intraocular lenses. Participants are adults with age-related cataract undergoing bilateral phacoemulsification, followed at multiple postoperative time points from 1 week to 6 months. Standard ophthalmic tests and validated questionnaires, including the MMAQ, are used to track changes in visual performance, spectacle independence, and overall satisfaction. The study aims to describe trajectories of neuroadaptation to optical phenomena such as glare and halos in real-world conditions. Interventions are observational in nature, involving various bilateral IOL strategies, without randomization or assignment by the researchers.
Why it matters
Potential benefit: If successful, results could guide doctors in choosing IOL strategies that optimize patient satisfaction and visual function after cataract surgery.
How similar studies have gone: Previous research has shown variable neuroadaptation to multifocal IOLs; this study adds longitudinal data on adaptation trajectories with mix-and-match strategies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older with age-related cataract requiring bilateral phacoemulsification and intraocular lens (IOL) implantation * Corneal astigmatism less than 0.75 D * Good general health and willing to complete all postoperative follow-up visits * Signed written informed consent Exclusion Criteria: * Previous ocular surgery or ocular trauma * Coexisting ocular diseases affecting visual potential, such as corneal opacity, glaucoma, macular degeneration, or diabetic retinopathy * Intraoperative or postoperative complications (e.g., posterior capsule rupture) * Systemic diseases that may interfere with visual outcomes or follow-up compliance
Where it's running
-
Sichuan Provincial People's Hospital
Chengdu, China Recruiting
Study contacts
- Principal investigator: Chao Qu — School of Medicine, University of Electronic Science and Technology of China
- Study coordinator: Xiangjun Fu, Ph.D.
- Email: 243981469@qq.com
- Phone: +86-28-87393999
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.