Condition

Bronchopulmonary Dysplasia clinical trials and research

• 28Clinical trials
• 36NIH research projects
• 13Countries

Newest Bronchopulmonary Dysplasia clinical trials

All recruiting trials (28)

• Lung Ultrasound Score to predict BPD in very preterm babies

  This study tests whether lung ultrasound scores in the first two weeks of life can predict which extremely preterm babies will develop bronchopulmonary dysplasia.

  Recruiting at 4 sites Azienda USL Reggio Emilia - IRCCS · Modena and 3 other locations · NCT07633184

• Caffeine in pregnancy: how the mother and baby handle it during delivery

  This study tests how caffeine is processed in pregnant people and how much reaches the baby when given shortly before delivery.

  Recruiting Phase 1 Indiana University · Indianapolis, Indiana · NCT07570121

• IVIG for bronchopulmonary dysplasia in infants born at 28 weeks or earlier

  This trial will try intravenous immunoglobulin (IVIG) given over five days to see if it helps very preterm infants (≤28 weeks) who show early signs of bronchopulmonary dysplasia.

  Recruiting Phase 2 International Peace Maternity and Child Health Hospital · Shanghai · NCT07561125

• High-energy DHA/ARA-enriched human milk in the first 2 weeks to lower lung problems in extremely preterm babies

  This trial tests whether giving DHA/ARA-enriched, fortified human milk in the first 14 days after birth helps extremely preterm infants breathe easier and have better lung function.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT07307612

• Reduced versus higher daily fluids to prevent bronchopulmonary dysplasia in very preterm babies

  This tests whether giving smaller daily fluid volumes from day 8 of life (about 135 mL/kg/day) instead of larger volumes (about 165 mL/kg/day) lowers the chance of developing BPD or dying before 36 weeks in babies born before 30 weeks.

  Recruiting at 9 sites University Children's Hospital Basel · Aarau and 8 other locations · NCT06954142

• Using IVIG to treat bronchopulmonary dysplasia in premature infants

  This study is testing if a special immune treatment called IVIG can help premature babies with breathing problems caused by bronchopulmonary dysplasia feel better.

  Recruiting Phase 2 International Peace Maternity and Child Health Hospital · Shanghai, Shanghai Municipality · NCT06925360

• Comparing two IV lipid infusions for very preterm or very low birth weight infants

  This study will try two types of intravenous lipid emulsions (mixed-oil vs soybean-oil) in extremely preterm or very low birth weight infants to see which better prevents bronchopulmonary dysplasia and supports growth and brain development.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06915441

• Zelpultide Alfa to reduce bronchopulmonary dysplasia risk in extremely premature babies

  This trial will try Zelpultide Alfa in extremely premature infants on ventilators to see if it lowers their chance of developing bronchopulmonary dysplasia.

  Recruiting at 47 sites Phase 2/3 Airway Therapeutics, Inc. · Buenos Aires and 48 other locations · NCT06897839

• Comparing gastric and transpyloric feeding in infants with severe bronchopulmonary dysplasia

  This study is testing whether feeding hospitalized infants with severe bronchopulmonary dysplasia through their stomach or directly into their intestines helps improve their breathing better.

  Recruiting Le Bonheur Children's Hospital · Memphis, Tennessee · NCT06821776

• Inhaled ciclesonide for preterm infants at risk of lung disease

  This study is testing if inhaled ciclesonide is a safer option than traditional treatments for preventing lung disease in preterm infants born before 30 weeks.

  Recruiting Phase 1 Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT06589245

• Using pressure-sensing mattresses to monitor breathing in newborns

  This study is testing if special pressure-sensing mattresses can help monitor breathing and heart rate in premature babies receiving breathing support, to see if they can predict breathing problems more comfortably than traditional methods.

  Recruiting Fu Jen Catholic University · New Taipei City · NCT06579157

• Transpyloric versus gastric feeding for premature infants with bronchopulmonary dysplasia

  This trial will see if feeding premature infants with bronchopulmonary dysplasia directly into the small intestine (transpyloric) versus into the stomach reduces reflux and episodes of low oxygen.

  Recruiting at 3 sites Children's Hospital of Philadelphia · Palo Alto, California and 3 other locations · NCT06534359

• Adjusting ventilator PEEP to improve lung compliance and heart function in preterm infants

  We will try changing the ventilator's PEEP settings in babies born before 34 weeks who need breathing support to see if the PEEP that gives the best lung compliance improves heart output and oxygen levels.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06512935

• Classification of severe bronchopulmonary dysplasia in infants

  This study is trying to create a new way to classify the most severe form of bronchopulmonary dysplasia in infants to see how different types of the condition affect their breathing and brain development over time.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06475976

• Comparing higher versus lower oxygen targets for very preterm infants with BPD-related pulmonary hypertension

  This trial will see if keeping very preterm infants with bronchopulmonary dysplasia and pulmonary hypertension at a slightly higher oxygen saturation (95–98%) versus a lower saturation (92–95%) helps them do better.

  Recruiting at 2 sites University of Alabama at Birmingham · Birmingham, Alabama and 1 other locations · NCT06373289

• Investigating biomarkers for early prediction of bronchopulmonary dysplasia in preterm infants

  This study is trying to find early signs that can help predict if premature babies will develop bronchopulmonary dysplasia, using samples from their breath, throat, and placenta.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06342752

• Using extracellular vesicles to prevent lung disease in premature infants

  This study is testing a new treatment using special cells from umbilical cords to see if it can help prevent lung disease in very premature infants.

  Recruiting at 2 sites Phase 1/2 EXO Biologics S.A. · Brussels and 7 other locations · NCT06279741

• Using stem cells to treat lung disease in preterm newborns

  This study is testing if giving preterm newborns stem cells from umbilical cords can help prevent lung disease called bronchopulmonary dysplasia while they are on breathing machines.

  Recruiting at 7 sites Phase 2 Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Pozuelo de Alarcón, Madrid and 6 other locations · NCT06270199

• Standardized oral care using human milk for premature infants in the NICU

  This study is trying to see if giving regular oral care using human milk can help very low birth weight babies in the NICU stay healthier and avoid complications.

  Recruiting University of Florida · Gainesville, Florida · NCT06000761

• Optimizing oxygen levels for premature infants during resuscitation

  This study is testing which oxygen level is best for helping premature babies during resuscitation at birth to improve their chances of survival and long-term health.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05849077

• Postpyloric feedings to improve lung health in preterm infants

  This study is testing if feeding preterm infants directly into their intestines can help improve their lung health better than regular feeding through the nose.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05777512

• Comparing two non-invasive ventilation methods for preterm infants after extubation

  This study is testing whether a new breathing support method is better than a standard one for extremely preterm infants who are coming off a ventilator to see if it helps them avoid complications.

  Recruiting at 19 sites University of Pennsylvania · Little Rock, Arkansas and 19 other locations · NCT05446272

• Improving discharge care for preterm infants with lung disease

  This study is testing a new care plan for preterm infants with lung disease to see if it helps them transition better from the hospital to home and improves their health and parents' satisfaction.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05285345

• Understanding how drugs work in children

  This study is trying to find the best and safest doses of certain medications for children and young adults under 21 who are being treated for conditions like COVID-19 and pulmonary arterial hypertension.

  Recruiting at 5 sites Duke University · Phoenix, Arizona and 51 other locations · NCT04278404

• Measuring lung function in infants with bronchopulmonary dysplasia

  This study is testing a new device to measure lung function in sleeping infants with bronchopulmonary dysplasia to help better understand their breathing problems.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT04270045

• Evaluating a new imaging system for pediatric respiratory diseases

  This study is testing a new imaging system to see if it can help monitor breathing in children with respiratory diseases and compare it to healthy kids.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT03797183

• Using MRI to study lung development in infants with Bronchopulmonary Dysplasia

  This study is testing how MRI scans can help us understand lung development in premature infants with Bronchopulmonary Dysplasia by comparing them to infants without the condition.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT03657693

• Using stem cells to prevent lung disease in premature infants

  This study is testing if giving special stem cells from umbilical cords can help prevent lung disease in premature babies who are at high risk.

  Recruiting Phase 1 Meridigen Biotech Co., Ltd. · Tainan · NCT03631420

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Role of uneven lung growth in chronic lung disease from birth to adulthood

  This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11412719

• Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults

  This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11399081

• Understanding how breathing effort in premature babies with lung disease comes from different lung problems

  A research project aims to create a patient-specific tool to measure how different features of bronchopulmonary dysplasia contribute to the struggle to breathe in premature infants.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11396353

• Role of LKB1 in reduced lung blood vessel growth in BPD

  Aims to understand how a cellular regulator (LKB1) affects blood vessel formation in the lungs of preterm infants at risk for bronchopulmonary dysplasia.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11378318

• A new approach to prevent bronchopulmonary dysplasia in preterm infants

  A new treatment strategy aimed at improving lung development in premature babies at risk for bronchopulmonary dysplasia.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11361527

• L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies

  A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11342260

• Metabolic clues to BPD-related pulmonary hypertension in babies and teens and adults

  This grant aims to understand why a serious lung condition in preterm babies can lead to high blood pressure in the lungs, with the goal of finding new treatments.

  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11319025

• Developing a new treatment for bronchopulmonary dysplasia in infants

  This study is working on a new medicine to help treat bronchopulmonary dysplasia (BPD) in premature babies, and the researchers are making sure it’s safe to test in humans so that it can eventually be available to those who need it.

  NIH research Reneurogen, LLC · Elm Grove, United States · NIH-11311467

• AVR-48: a new lung medicine to help premature babies prevent lung disease

  A small molecule medicine called AVR-48 is being studied to help premature babies avoid a serious lung disease called bronchopulmonary dysplasia.

  NIH research Ayuvis Research, INC. · Fort Worth, United States · NIH-11309117

• DLL4 and newborn lung development in bronchopulmonary dysplasia

  This work looks at whether restoring a protein called DLL4 can help blood vessel and air sac growth in premature babies with bronchopulmonary dysplasia (BPD).

  NIH research Children's Mercy Hosp (Kansas City, Mo) · Kansas City, United States · NIH-11308222

• Role of Surfactant Protein A and SP-R210 Signaling in Bronchopulmonary Dysplasia

  This NIH grant focuses on how surfactant protein A and its receptor in lung immune cells contribute to bronchopulmonary dysplasia in premature babies.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11282206

• Parent-reported breathing and care issues when preterm babies with BPD go home

  This project collects parents' reports to find breathing problems and care barriers for preterm infants with bronchopulmonary dysplasia as they leave the NICU and enter early childhood.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11269215

• New treatments for lung problems in premature infants

  This study is looking for new ways to help premature babies who have bronchopulmonary dysplasia and high blood pressure in their lungs, with the goal of making them healthier and reducing serious health risks.

  NIH research Yale University · New Haven, United States · NIH-11239367

• How different lung problems add to breathing effort in premature babies with bronchopulmonary dysplasia

  This project will build a tool that estimates how much each lung problem makes a premature baby with bronchopulmonary dysplasia work harder to breathe.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11169664

• How the LKB1 protein affects blood vessel and lung growth in babies with bronchopulmonary dysplasia

  This research is seeing if targeting a cell energy protein (LKB1/AMPK) can help restore blood vessel and lung growth in premature infants at risk for bronchopulmonary dysplasia.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11135377

• Understanding how metabolic processes affect lung disease in premature infants

  This study is looking at how certain changes in the lungs of premature babies with bronchopulmonary dysplasia can lead to high blood pressure in the lungs, and it hopes to find new ways to help treat or prevent this condition.

  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11092333

• Investigating a new treatment to prevent lung disease in premature infants

  This study is testing a new medication called AVR-48 to see if it can help prevent lung problems in premature babies, aiming to improve their breathing and overall health.

  NIH research Ayuvis Research, INC. · Fort Worth, United States · NIH-11074691

• Using aerosolized vitamin A to help prevent lung injury in premature infants

  This study is testing a gentle way to give preterm babies a special vitamin A mist to help prevent lung problems and vitamin A deficiency, so they can avoid painful shots and get the nutrients they need more easily.

  NIH research Advent Therapeutics, INC. · Lumberville, United States · NIH-11060999

• Understanding how to improve care for infants with bronchopulmonary dysplasia as they transition from the NICU to home

  This study is all about finding better ways to support families of babies with bronchopulmonary dysplasia (BPD) as they transition from the hospital to home, by understanding their challenges and creating helpful tools to improve their health and care.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11046004

• Investigating the role of DLL4 in lung development and bronchopulmonary dysplasia in premature infants

  This study is looking at how a protein called DLL4 impacts lung growth in premature babies, especially those at risk for a serious lung problem called bronchopulmonary dysplasia (BPD), to find ways to help their lungs develop better.

  NIH research Children's Mercy Hosp (Kansas City, Mo) · Kansas City, United States · NIH-11017750

• Identifying kidney-related risk factors for severe lung disease in premature infants

  This study is looking at how kidney problems and too much fluid can lead to serious lung issues in premature babies, and it aims to help doctors spot which babies might be at risk so they can provide better care and improve their health.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10991668

• Comparing two feeding methods for very preterm infants with lung disease

  This study is looking at whether feeding very premature babies through a different route (transpyloric feeding) instead of the usual method (gastric feeding) can help improve their health and reduce problems like reflux, especially for those with a serious lung condition called bronchopulmonary dysplasia (BPD).

  NIH research Stanford University · Stanford, United States · NIH-10987709

• Investigating how liver kinase B1 affects blood vessel growth in premature infants with lung complications

  This study is exploring how too much oxygen can affect the lung growth of premature babies with bronchopulmonary dysplasia, and it’s looking at a specific protein that might help improve blood vessel development in their lungs to find better treatments for them.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-10940315

• Investigating a factor in lung development and its role in a common neonatal lung disease

  This study is looking at how a protein called CCN2 helps newborns' lungs grow and heal, with the goal of finding new ways to treat bronchopulmonary dysplasia (BPD) in premature babies.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-10903832

• Using saliva to predict lung complications in premature infants

  This study is looking at how tiny molecules in saliva might help doctors predict lung problems in premature babies, so they can catch issues early and provide better care.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10895439

• Investigating furosemide treatment strategies for severe bronchopulmonary dysplasia in infants

  This study is looking at how different amounts and lengths of a medicine called furosemide can help improve the health of premature babies with a serious lung condition called bronchopulmonary dysplasia (BPD).

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10893331

• Creating a new treatment for bronchopulmonary dysplasia in preterm infants

  This study is testing a new treatment for bronchopulmonary dysplasia (BPD) in preterm babies, using a special compound that helps reduce lung stress and inflammation, with the hope of making their lungs healthier and improving their overall well-being.

  NIH research Reneurogen, LLC · Elm Grove, United States · NIH-10888168

• The connection between gut health and lung development in newborns

  This study is looking at how tiny fungi in the gut might influence lung health in newborns, especially those at risk for bronchopulmonary dysplasia (BPD), to help find better treatments for these little ones.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10871879

• Investigating how IL-33 affects lung injury in premature infants

  This study is looking at how a protein called IL-33 might be linked to lung problems in premature babies with bronchopulmonary dysplasia (BPD), and the researchers hope to find new ways to help these little ones breathe better.

  NIH research University of Washington · Seattle, United States · NIH-10865078

• Understanding breathing difficulties in premature babies with lung disease

  This study is looking at babies who were born early and have breathing problems called bronchopulmonary dysplasia (BPD), and it aims to create a helpful tool that will figure out how their lungs work so doctors can give them the best care for their specific breathing needs.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10858162

• Understanding lung disease in premature infants through metabolic changes

  This study is looking at how the metabolism of preterm babies with bronchopulmonary dysplasia (BPD) changes over time by collecting and analyzing their urine and lung fluid, with the goal of finding better ways to care for these little ones.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10808882

• Investigating how vitamin D affects lung development and chronic lung disease in infants

  This study is looking at how vitamin D might help improve lung development in premature babies and protect them from a lung condition called bronchopulmonary dysplasia (BPD), using mouse models to learn more about how it works.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10765733

• Investigating the safety of sildenafil for premature infants with severe lung disease

  This study is looking at whether sildenafil can safely help prevent lung problems in premature babies with severe breathing issues, and it involves giving some babies the medication and others a placebo to see how well it works.

  NIH research Duke University · Durham, United States · NIH-10694036

• Testing inhaled tobramycin for very preterm infants with lung disease

  This study is looking at how inhaled tobramycin, an antibiotic, can help very preterm babies with bronchopulmonary dysplasia (BPD) by delivering the medicine straight to their lungs to fight harmful bacteria and improve their breathing.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10688294

• How indoor air quality affects children with lung issues from premature birth

  This study looks at how the air quality inside homes affects the breathing health of school-aged kids with bronchopulmonary dysplasia, a lung condition from being born early, to find ways to help them breathe better.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10540413

• Inhaled treatment for chronic lung disease in infants

  This study is looking at how inhaling ethyl nitrite might help improve lung function and oxygen levels in premature babies with bronchopulmonary dysplasia, a serious lung condition, by making their lungs work better.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10455406

Related topics

Quick answers

How many Bronchopulmonary Dysplasia clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (18 trials), Belgium (3 trials), Italy (3 trials), Taiwan (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 3, Phase 1/2: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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