Optimizing oxygen levels for premature infants during resuscitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to determine the optimal target oxygen saturation (SpO2) range for preterm infants during resuscitation at birth to improve survival rates and reduce long-term health issues. It will compare two different SpO2 targets, Sat75 and Sat50, to assess their impact on neonatal outcomes. The research addresses a critical gap in knowledge regarding oxygen use in neonatal resuscitation, as current guidelines are based on expert opinion rather than empirical evidence. By refining oxygen saturation targets, the study seeks to balance the risks of hypoxia and oxygen toxicity in vulnerable preterm infants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

-Neonates with OB gestational age 22-30 weeks

Exclusion Criteria:

* Prenatally diagnosed cyanotic congenital heart disease
* Prenatally diagnosed congenital diaphragmatic hernia
* Parents request no resuscitation
* If preductal saturations can not be measured by 3 minutes after pulse oximeter sensor is applied to the newborn

Where it's running

• University of Texas Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Vishal Kapadia, MD — University of Texas Southwestern Medical Center
• Study coordinator: Vishal Kapadia, MD
• Email: vishal.kapadia@utsouthwestern.edu
• Phone: 2146483903

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Lung Ultrasound Score to predict BPD in very preterm babies

  This study tests whether lung ultrasound scores in the first two weeks of life can predict which extremely preterm babies will develop bronchopulmonary dysplasia.

  Recruiting at 4 sites Azienda USL Reggio Emilia - IRCCS · Modena and 3 other locations · NCT07633184

• Caffeine in pregnancy: how the mother and baby handle it during delivery

  This study tests how caffeine is processed in pregnant people and how much reaches the baby when given shortly before delivery.

  Recruiting Phase 1 Indiana University · Indianapolis, Indiana · NCT07570121

• IVIG for bronchopulmonary dysplasia in infants born at 28 weeks or earlier

  This trial will try intravenous immunoglobulin (IVIG) given over five days to see if it helps very preterm infants (≤28 weeks) who show early signs of bronchopulmonary dysplasia.

  Recruiting Phase 2 International Peace Maternity and Child Health Hospital · Shanghai · NCT07561125

• Massage to improve sleep, comfort, and vital signs in preterm infants

  This trial will see if giving medically stable preterm infants (35–37 weeks) a 15-minute massage three times a day for three days in the NICU improves sleep, reduces stress, increases comfort, and stabilizes vital signs compared with standard care.

  Recruiting Yuzuncu Yil University · Van, Turkey · NCT07322731

• High-energy DHA/ARA-enriched human milk in the first 2 weeks to lower lung problems in extremely preterm babies

  This trial tests whether giving DHA/ARA-enriched, fortified human milk in the first 14 days after birth helps extremely preterm infants breathe easier and have better lung function.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT07307612

• Looking at tiny particles in cord blood of babies born before 28 weeks

  The team will test whether extracellular vesicles in umbilical cord blood can help predict serious complications in babies born before 28 weeks of pregnancy.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07273643

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.