New treatments for lung problems in premature infants

Who could benefit from this research

What this research studies

This research focuses on developing new therapeutic strategies to manage bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) in infants. Dr. Samuel Gentle aims to reduce the high rates of morbidity and mortality associated with this condition, which affects many premature infants. The research will involve innovative translational and interventional approaches, potentially leading to multi-center clinical trials that could improve outcomes for these vulnerable patients. The project is supported by a strong mentorship team with extensive experience in related research.

Why it matters

Where this research is happening

• Yale University
  New Haven, United States Active

Researchers

• Principal investigator: Gentle, Samuel J — Yale University
• Study coordinator: Gentle, Samuel J

Related research

Other NIH-funded projects on the same topics.

• Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults

  This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11399081

• L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies

  A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11342260

• Metabolic clues to BPD-related pulmonary hypertension in babies and teens and adults

  This grant aims to understand why a serious lung condition in preterm babies can lead to high blood pressure in the lungs, with the goal of finding new treatments.

  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11319025

• Understanding how metabolic processes affect lung disease in premature infants

  This study is looking at how certain changes in the lungs of premature babies with bronchopulmonary dysplasia can lead to high blood pressure in the lungs, and it hopes to find new ways to help treat or prevent this condition.

  NIH research Ocean State Research Institute, INC. · Providence, United States · NIH-11092333

• Using saliva to predict lung complications in premature infants

  This study is looking at how tiny molecules in saliva might help doctors predict lung problems in premature babies, so they can catch issues early and provide better care.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10895439

• Understanding how CD4 T cells fuel schistosomiasis-related lung disease

  A study explores how specific immune cells and inflammatory signals in schistosomiasis may contribute to pulmonary hypertension in people affected by the disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11606580

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.