Lung Ultrasound Score to predict BPD in very preterm babies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses lung ultrasound performed at about 7 and 14 days after birth to identify early lung‑aeration patterns that may predict bronchopulmonary dysplasia in infants born before 32 weeks. The Lung Ultrasound Score quantifies aeration loss and pleural line abnormalities to help forecast later respiratory outcomes. The goal is to enable earlier, targeted interventions by identifying high‑risk infants before 36 weeks postmenstrual age. Data are collected from multiple neonatal centers to evaluate the association between early LUS findings and subsequent BPD development. No therapeutic interventions are assigned as part of this observational assessment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* born at less than 32 weeks' gestational age;
* born in the Neonatology Department of one of the centres participating in the study or transferred there from another hospital within the first week of life;
* parents/guardians have signed an informed consent form regarding the inclusion of thenewborn in the study and consent to the processing of personal data

Exclusion Criteria:

* major malformations,chromosomal abnormalities, congenital chest wall deformities, congenital heart defects, pulmonary hypoplasia, diaphragmatic hernia, suspected muscular dystrophy or neurological disorders that may impair lung development;
* receipt of palliative care from birth;
* death before 36 weeks' gestational age;
* inability to perform a chest ultrasound or to adequately examine all 6 lung fields at both 7 (+/-1) and 14 (+/-2) days for any intervening reason;
* inability to collect the data necessary to formulate a diagnosis of BPD within the duration of the study

Where it's running

• Neonatology and Neonatal Intensive Care Unit AOU Policlinico Modena
  Modena, Italy Recruiting
• Neonatology and Neonatal Intensive Care Unit AOU Padova
  Padova, Italy Recruiting
• Neonatology and Neonatal Intensive Care Unit AUSL - IRCCS of Reggio Emilia
  Reggio Emilia, Italy Recruiting
• Neonatology and Neonatal Intensive Care Unit Policlinico Universitario A. Gemelli IRCCS, Roma.
  Roma, Italy Recruiting

Study contacts

• Study coordinator: Eleonora Balestri, MD
• Email: eleonora.baIestri@ausl.re.it
• Phone: 0522 296278

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Caffeine in pregnancy: how the mother and baby handle it during delivery

  This study tests how caffeine is processed in pregnant people and how much reaches the baby when given shortly before delivery.

  Recruiting Phase 1 Indiana University · Indianapolis, Indiana · NCT07570121

• IVIG for bronchopulmonary dysplasia in infants born at 28 weeks or earlier

  This trial will try intravenous immunoglobulin (IVIG) given over five days to see if it helps very preterm infants (≤28 weeks) who show early signs of bronchopulmonary dysplasia.

  Recruiting Phase 2 International Peace Maternity and Child Health Hospital · Shanghai · NCT07561125

• High-energy DHA/ARA-enriched human milk in the first 2 weeks to lower lung problems in extremely preterm babies

  This trial tests whether giving DHA/ARA-enriched, fortified human milk in the first 14 days after birth helps extremely preterm infants breathe easier and have better lung function.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT07307612

• Reduced versus higher daily fluids to prevent bronchopulmonary dysplasia in very preterm babies

  This tests whether giving smaller daily fluid volumes from day 8 of life (about 135 mL/kg/day) instead of larger volumes (about 165 mL/kg/day) lowers the chance of developing BPD or dying before 36 weeks in babies born before 30 weeks.

  Recruiting at 9 sites University Children's Hospital Basel · Aarau and 8 other locations · NCT06954142

• Using IVIG to treat bronchopulmonary dysplasia in premature infants

  This study is testing if a special immune treatment called IVIG can help premature babies with breathing problems caused by bronchopulmonary dysplasia feel better.

  Recruiting Phase 2 International Peace Maternity and Child Health Hospital · Shanghai, Shanghai Municipality · NCT06925360

• Comparing two IV lipid infusions for very preterm or very low birth weight infants

  This study will try two types of intravenous lipid emulsions (mixed-oil vs soybean-oil) in extremely preterm or very low birth weight infants to see which better prevents bronchopulmonary dysplasia and supports growth and brain development.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06915441

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.