Reduced versus higher daily fluids to prevent bronchopulmonary dysplasia in very preterm babies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Bronchopulmonary dysplasia (BPD) is a common chronic lung problem in babies born very preterm and is associated with prolonged respiratory support and long-term health issues. This trial randomizes hospitalized infants born before 30 weeks to either a restricted fluid regimen (135 ±5 mL/kg/day) or a liberal regimen (165 ±5 mL/kg/day) starting on day 8 of life. The primary outcome is BPD at 36 weeks postmenstrual age or death prior to that age, with monitoring of respiratory support, growth, and safety outcomes. The approach aims to reduce pulmonary interstitial edema without exposing infants to the risks of routine diuretic use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospitalised preterm infants born before 30 weeks 0 days gestation
* Signed informed consent for further research use of health-related data

Exclusion Criteria:

* congenital malformations
* diseases likely to affect life expectancy, lung function, fluid strategy, or neurodevelopment
* renal disease requiring fluid management outside the clinical standard of care
* congenital heart disease not including patent ductus arteriosus (PDA)

Where it's running

• Kantonsspital Aarau AG, Klinik für Kinder u. Jugendliche
  Aarau, Switzerland Recruiting
• University Children's Hospital Basel (UKBB)
  Basel, Switzerland Recruiting
• Inselspital Bern, Kinderklinik
  Bern, Switzerland Recruiting
• Kantonsspital Graubünden, Departement Kinder- und Jugendmedizin
  Chur, Switzerland Recruiting
• Hôpitaux universitaires de Genève (HUG), Service de Néonatologie et Soins Intensifs
  Geneva, Switzerland Recruiting
• Centre hospitalier universitaire vaudois (CHUV) - Service de néonatologie
  Lausanne, Switzerland Recruiting

Study contacts

• Principal investigator: Sven Schulzke, Prof.MD — University Children's Hospital Basel
• Study coordinator: Anne Carrer
• Email: anne.carrer@ukbb.ch
• Phone: +4161 704 2853

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Lung Ultrasound Score to predict BPD in very preterm babies

  This study tests whether lung ultrasound scores in the first two weeks of life can predict which extremely preterm babies will develop bronchopulmonary dysplasia.

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• Caffeine in pregnancy: how the mother and baby handle it during delivery

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  Recruiting Phase 1 Indiana University · Indianapolis, Indiana · NCT07570121

• IVIG for bronchopulmonary dysplasia in infants born at 28 weeks or earlier

  This trial will try intravenous immunoglobulin (IVIG) given over five days to see if it helps very preterm infants (≤28 weeks) who show early signs of bronchopulmonary dysplasia.

  Recruiting Phase 2 International Peace Maternity and Child Health Hospital · Shanghai · NCT07561125

• High-energy DHA/ARA-enriched human milk in the first 2 weeks to lower lung problems in extremely preterm babies

  This trial tests whether giving DHA/ARA-enriched, fortified human milk in the first 14 days after birth helps extremely preterm infants breathe easier and have better lung function.

  Recruiting Phase 1/2 University of Alabama at Birmingham · Birmingham, Alabama · NCT07307612

• Using IVIG to treat bronchopulmonary dysplasia in premature infants

  This study is testing if a special immune treatment called IVIG can help premature babies with breathing problems caused by bronchopulmonary dysplasia feel better.

  Recruiting Phase 2 International Peace Maternity and Child Health Hospital · Shanghai, Shanghai Municipality · NCT06925360

• Comparing two IV lipid infusions for very preterm or very low birth weight infants

  This study will try two types of intravenous lipid emulsions (mixed-oil vs soybean-oil) in extremely preterm or very low birth weight infants to see which better prevents bronchopulmonary dysplasia and supports growth and brain development.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06915441

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.