Investigating how liver kinase B1 affects blood vessel growth in premature infants with lung complications
Official title: Role of Liver Kinase B1 in the decreased angiogenesis in bronchopulmonary dysplasia
Funded at Medical College of Wisconsin · NIH-10940315 · Data updated 2026-11-12
This study is exploring how too much oxygen can affect the lung growth of premature babies with bronchopulmonary dysplasia, and it’s looking at a specific protein that might help improve blood vessel development in their lungs to find better treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $645,450 |
| NIH project number | 1R01HL174635-01 |
| Project ID | NIH-10940315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants who are at risk of developing bronchopulmonary dysplasia due to exposure to supplemental oxygen.
✕Less likely to help
Patients who are not premature or do not have bronchopulmonary dysplasia may not benefit from this research.
What this research studies
This research focuses on understanding bronchopulmonary dysplasia (BPD), a serious lung condition that affects premature infants. It examines how exposure to high levels of oxygen can hinder the growth of blood vessels in the lungs, which is crucial for healthy lung development. The study looks at the role of liver kinase B1 (LKB1) and its impact on a key metabolic regulator, AMPK, in promoting blood vessel formation. By using a neonatal mouse model, the researchers aim to identify potential treatments that could improve lung health in affected infants.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung development and reduce complications in premature infants suffering from BPD.
How similar studies have gone: Previous studies have shown promising results in using metabolic regulators like AMPK activators to improve lung function in similar conditions, suggesting a potential for success in this approach.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Konduri, Girija G. — Medical College of Wisconsin
- Study coordinator: Konduri, Girija G.
Related research
Other NIH-funded projects on the same topics.
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Role of uneven lung growth in chronic lung disease from birth to adulthood
This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.
-
Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults
This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.
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Understanding how breathing effort in premature babies with lung disease comes from different lung problems
A research project aims to create a patient-specific tool to measure how different features of bronchopulmonary dysplasia contribute to the struggle to breathe in premature infants.
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Role of LKB1 in reduced lung blood vessel growth in BPD
Aims to understand how a cellular regulator (LKB1) affects blood vessel formation in the lungs of preterm infants at risk for bronchopulmonary dysplasia.
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A new approach to prevent bronchopulmonary dysplasia in preterm infants
A new treatment strategy aimed at improving lung development in premature babies at risk for bronchopulmonary dysplasia.
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L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies
A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.