Investigating how liver kinase B1 affects blood vessel growth in premature infants with lung complications
Role of Liver Kinase B1 in the decreased angiogenesis in bronchopulmonary dysplasia
This study is exploring how too much oxygen can affect the lung growth of premature babies with bronchopulmonary dysplasia, and it’s looking at a specific protein that might help improve blood vessel development in their lungs to find better treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10940315 on NIH RePORTER |
What this research studies
This research focuses on understanding bronchopulmonary dysplasia (BPD), a serious lung condition that affects premature infants. It examines how exposure to high levels of oxygen can hinder the growth of blood vessels in the lungs, which is crucial for healthy lung development. The study looks at the role of liver kinase B1 (LKB1) and its impact on a key metabolic regulator, AMPK, in promoting blood vessel formation. By using a neonatal mouse model, the researchers aim to identify potential treatments that could improve lung health in affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who are at risk of developing bronchopulmonary dysplasia due to exposure to supplemental oxygen.
Not a fit: Patients who are not premature or do not have bronchopulmonary dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung development and reduce complications in premature infants suffering from BPD.
How similar studies have performed: Previous studies have shown promising results in using metabolic regulators like AMPK activators to improve lung function in similar conditions, suggesting a potential for success in this approach.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Konduri, Girija G. — Medical College of Wisconsin
- Study coordinator: Konduri, Girija G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.