Condition

Down Syndrome clinical trials and research

• 48Clinical trials
• 311NIH research projects
• 1New in 30 days
• 12Countries

Newest Down Syndrome clinical trials

All recruiting trials (48)

• Kinematic analysis of hand and arm movement in kids with Down syndrome, CP and healthy children

  This study tests how well an instrumented Box and Block Test and motion tracking can measure upper-limb movement in healthy kids and those with pyramidal hemisyndrome or Down syndrome.

  Recruiting IRCCS San Raffaele Roma · Rome, Italiy · NCT07875127

• Sensory integration to help balance and movement in kids with Down syndrome

  Aimed at seeing if adding sensory integration to physical therapy helps improve gross motor skills and balance in children with Down syndrome.

  Recruiting Cairo University · Cairo · NCT07785011

• Collaboration for Down Syndrome Progress (CDP) in people with Down syndrome

  A long-term study following people with Down syndrome of all ages to see how health and everyday life change over time.

  Recruiting RTI International · Orange, California and 15 other locations · NCT07625579

• JAK inhibitor treatment for Down syndrome in children and young adults

  This study tests whether 6 months of tofacitinib can help improve safety and neurodevelopment in people with Down syndrome aged 6 to 22, compared with placebo.

  Recruiting Phase 2 University of Colorado, Denver · Aurora, Colorado · NCT07598643

• Jump rope to improve navicular drop and foot posture in children with Down syndrome

  This project will test whether adding jump-rope exercises to play activities helps improve foot posture in 4–15-year-old children with Down syndrome who have navicular drop.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07428863

• Thymus removal and immune aging in people with Down syndrome

  This study will try to see if removing part of the thymus affects immune health over time in people aged 1 and older with Down syndrome, comparing those who had thymectomy to those who did not and to unaffected household relatives.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07416201

• Immune and breathing measurements in children with Down syndrome and pneumonia

  This project tests whether blood immune markers and simple breathing measures are linked in children with Down syndrome who have acute pneumonia.

  Recruiting at 2 sites Badr University · Cairo and 1 other locations · NCT07366593

• Endotype-directed treatment for obstructive sleep apnea in people with Down syndrome

  This project will test whether a precision approach—using atomoxetine plus oxybutynin for some people and oxygen for others based on breathing patterns—works better than giving atomoxetine-plus-oxybutynin to everyone with Down syndrome and obstructive sleep apnea.

  Recruiting at 5 sites Phase 4 University of Arizona · Tucson, Arizona and 4 other locations · NCT07280468

• Cuevas Medek versus rebound exercises to improve physical fitness in children with Down syndrome

  This trial will test whether Cuevas Medek exercises or rebound (trampoline-based) exercises better improve physical fitness in children with Down syndrome aged 3 to 8.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07248449

• Vojta therapy to improve walking and mobility in children with Down syndrome

  This trial will test whether an eight-week program of Vojta therapy can improve walking and overall mobility in children aged 2–10 with Down syndrome.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07248267

• Powerball exercises to improve arm endurance and coordination in children with Down syndrome

  This trial will try powerball exercises on static versus dynamic surfaces to see if they improve upper-arm endurance and coordination in children with Down syndrome aged 6–10.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07244133

• How the sympathetic (fight-or-flight) system works in adults with Down syndrome

  This study will test how the sympathetic nervous system responds to stressors like exercise, cold, pain, fear, and caffeine in adults with Down syndrome to see if their heart rate and blood pressure responses are reduced or altered.

  Recruiting Phase 3 University of Colorado, Denver · Aurora, Colorado · NCT07238465

• Levetiracetam to prevent seizures in adults with Down syndrome and Alzheimer's disease

  This trial will test whether the anti-seizure medicine levetiracetam can prevent tonic-clonic seizures and slow cognitive decline in adults over 40 who have Down syndrome and symptomatic Alzheimer's disease.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Granada, Andalusia and 4 other locations · NCT07234695

• Does drumming help self-control in children with Down syndrome?

  In this study, 7- to 15-year-olds with Down syndrome try two months of drum lessons to see if it improves self-control and timing.

  Recruiting Vanderbilt University · Nashville, Tennessee · NCT07156318

• Non-invasive brain stimulation to improve language in people with Down syndrome.

  This project will test whether short sessions of transcranial direct current stimulation (tDCS) to the left frontal language area, combined with speech practice, can improve language in Italian-speaking adolescents and young adults with Down syndrome.

  Recruiting Bambino Gesù Hospital and Research Institute · Rome · NCT07044804

• Effects of Down Dog Yoga on Pre-writing Skills in Children With Down Syndrome

  This study tests if Down Dog yoga can help improve pre-writing skills in children aged 4-8 years with Down syndrome.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06977672

• Effects of 'Minds In Motion The Maze' on balance and gait in children with Down syndrome

  This study tests if a fun program called 'Minds In Motion: The Maze' can help improve balance and walking in children with Down syndrome aged 8 to 12.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06955052

• Evaluating how simplified language helps young children with Down syndrome learn

  This study tests if using simpler language helps young children with Down syndrome learn new words better than using full sentences.

  Recruiting Michigan State University · East Lansing, Michigan · NCT06951516

• Nordic walking to improve balance and strength in children with Down syndrome

  This study tests if Nordic walking can help improve balance and strength in children with Down syndrome aged 8-13 compared to regular exercise therapy.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06943508

• Effects of Aerobic Exercise and Diet on Weight in Children with Down Syndrome

  This study is testing whether kids with Down syndrome who are overweight can lose weight and improve their health by doing aerobic exercise alone or by combining it with a low-calorie diet.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06943170

• tDCS for catatonic depression in Down syndrome

  This study tests whether 15 sessions of brain stimulation (tDCS) can help mood and catatonia symptoms in adults with Down syndrome who have depression.

  Recruiting Hôpital le Vinatier · Lyon, Auvergne-Rhône-Alpes · NCT06866925

• Improving sleep quality in individuals with Down syndrome

  This study is testing a new online program to help young people with Down syndrome sleep better and feel happier in their daily lives.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06783725

• High Intensity Interval Training for Children with Down Syndrome

  This study is testing whether a special exercise program called High-Intensity Interval Training can help children with Down Syndrome improve their endurance and stability compared to regular physical therapy.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06777394

• Therapeutic taping effects on pelvic stability in children with Down syndrome

  This study tests if using therapeutic taping along with stability training can help improve pelvic stability in children with Down syndrome.

  Recruiting at 2 sites Riphah International University · Lahore, Punjab Province and 1 other locations · NCT06770218

• Inclusive physical activity program for adults with intellectual disabilities

  This study is testing a new fitness program for adults with intellectual disabilities to see if it helps them be more active and feel better over 16 weeks.

  Recruiting University of North Carolina, Chapel Hill · Fayetteville, Arkansas and 1 other locations · NCT06740162

• Comparing Swiss Ball and Frenkel Exercises for Children with Down Syndrome

  This study is testing whether Swiss Ball exercises or Frenkel exercises can help improve balance and coordination in children with Down syndrome.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06732713

• Investigating language development in children with communication challenges

  This study is testing new ways to measure language growth in preschoolers with communication challenges, like Down Syndrome and Cerebral Palsy, to see what helps them learn to talk better.

  Recruiting University of Central Florida · Orlando, Florida · NCT06512168

• Harness-based mobility intervention for infants with Down syndrome

  This study is testing a special harness to see if it can help infants with Down syndrome move better and interact more during playtime.

  Recruiting Boston University Charles River Campus · Boston, Massachusetts · NCT06219863

• Evaluating patterns in neurodevelopmental disorders

  This study is trying to find common signs and causes of neurodevelopmental disorders like Autism and Down Syndrome to help with earlier diagnosis and better outcomes for those affected.

  Recruiting Rossignol Medical Center · Phoenix, Arizona · NCT06213090

• Exploring sleep patterns and apnea in individuals with Down syndrome

  This study is trying to understand sleep problems, especially sleep apnea, in children with Down syndrome to help find ways to diagnose and treat these issues early.

  Recruiting University Hospital, Grenoble · La Tronche · NCT06061562

• Oxygen therapy for children with Down Syndrome and sleep apnea

  This study is testing whether giving extra oxygen during sleep can help improve thinking skills and overall health in children with Down Syndrome who have sleep apnea.

  Recruiting at 7 sites Phase 2 Brigham and Women's Hospital · Los Angeles, California and 6 other locations · NCT06043440

• Evaluating non-invasive ventilation for sleep apnea in children with Down syndrome

  This study is trying to see if using a non-invasive breathing machine can help children with Down syndrome who have sleep apnea sleep better and improve their quality of life.

  Recruiting at 2 sites Children's Health Ireland · Dublin and 5 other locations · NCT06030349

• Weight loss and dietary changes to prevent Alzheimer's in adults with Down syndrome

  This study is testing if losing weight or changing diets can help prevent or delay Alzheimer's in adults with Down syndrome.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT05985486

• Investigating genetic differences in twins with and without Down syndrome

  This study is trying to understand the genetic differences between twins, one with Down syndrome and one without, to see how these differences might affect their health and development.

  Recruiting Institut Jerome Lejeune · Paris · NCT05767216

• Analyzing genetic markers in patients with intellectual disabilities

  This study is trying to learn more about the genetic causes of intellectual disabilities, like Down Syndrome, by looking at blood and skin samples from patients to find better ways to diagnose and treat these conditions.

  Recruiting Institut Jerome Lejeune · Paris · NCT05767203

• Understanding the health of individuals with Down syndrome after leukemia treatment

  This study looks at the long-term health and quality of life of people with Down syndrome who have survived leukemia to see how it affects them compared to those who haven't had cancer.

  Recruiting at 73 sites Children's Oncology Group · Birmingham, Alabama and 72 other locations · NCT05702645

• Using a special airway device to treat sleep apnea in children with weak muscles

  This study is testing a special airway device to see if it can help children with weak muscles who have sleep apnea breathe better at night without needing surgery.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05527652

• Personalized surgery for obstructive sleep apnea in children with Down syndrome

  This study is testing a personalized surgery approach to treat obstructive sleep apnea in children with Down syndrome to see if it works better than standard surgery.

  Recruiting at 6 sites Oregon Health and Science University · Aurora, Colorado and 6 other locations · NCT05508971

• Cholinergic Integrity in Down Syndrome and Aging

  This study tests a brain imaging tracer to see if cholinergic nerve health declines with age in adults with Down syndrome who may be at risk for Alzheimer's disease.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05231798

• Gamma frequency stimulation for individuals with Down Syndrome

  This study is testing if a new light and sound treatment can help improve thinking skills and slow down Alzheimer's risk in people with Down Syndrome.

  Recruiting Massachusetts Institute of Technology · Cambridge, Massachusetts · NCT05196984

• Blinatumomab versus blinatumomab plus nivolumab for first-relapse CD19+ B‑ALL

  This test sees if adding nivolumab to blinatumomab helps children and young adults (ages 1–30) with first-relapse CD19+ B‑cell acute lymphoblastic leukemia, including people with Down syndrome.

  Recruiting at 154 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 226 other locations · NCT04546399

• GnRH therapy to improve cognition in individuals with Down syndrome

  This study is testing if a new hormone treatment can help improve thinking skills and smell in adults with Down syndrome who are at risk for early Alzheimer's disease.

  Recruiting Phase 2/3 Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud · NCT04390646

• Understanding how drugs work in children

  This study is trying to find the best and safest doses of certain medications for children and young adults under 21 who are being treated for conditions like COVID-19 and pulmonary arterial hypertension.

  Recruiting at 5 sites Duke University · Phoenix, Arizona and 51 other locations · NCT04278404

• Observational cohort for adults with Down syndrome and Alzheimer's disease

  This study is trying to understand how thinking skills relate to Alzheimer's disease signs in adults with Down syndrome to help plan future treatments.

  Recruiting at 18 sites University of Southern California · Phoenix, Arizona and 21 other locations · NCT04165109

• Evaluating retinal imaging for neurodegenerative diseases

  This study is testing if special eye scans can help spot early signs of neurodegenerative diseases like Alzheimer's and Parkinson's in people.

  Recruiting Duke University · Durham, North Carolina · NCT03233646

• Biobank for Down Syndrome Research

  This study is creating a biobank to collect health information and samples from people with Down syndrome to help researchers learn more about the condition and related health issues.

  Recruiting University of Colorado, Denver · Denver, Colorado · NCT02864108

• A registry for individuals with Down syndrome

  This study is creating an online registry for people with Down syndrome to share their health information and connect with research opportunities that could improve care and understanding of the condition.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT01950624

• Collecting samples from pregnant women at risk for fetal chromosomal abnormalities

  This study is testing a new blood test for pregnant women at risk of having a baby with Down syndrome to see if it can provide accurate results compared to traditional testing methods.

  Recruiting at 14 sites Sequenom, Inc. · Birmingham, Alabama and 13 other locations · NCT01429389

NIH-funded research (newest 40 of 311)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Exploring how Down syndrome affects optic nerve health in kids

  A study using a mouse model to understand why optic nerve problems are common in children with Down syndrome and how to prevent them.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11641009

• Executive Function Enhancement for Young Children with Down Syndrome

  A caregiver-guided program for kids with Down syndrome aged up to 11 to strengthen their thinking skills during early childhood.

  NIH research Colorado State University · Fort Collins, United States · NIH-11609228

• Silencing an Extra Chromosome to Help Down Syndrome and Related Conditions

  A patient-friendly plan to use a gene-based approach to quiet an extra chromosome in cells and a mouse model to reduce disease-related effects in Down syndrome and other chromosomal imbalance disorders.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11600903

• Infant Down Syndrome Brain and Behavior Study

  A study of infants with Down syndrome to collect brain imaging and developmental data, creating a large, shared resource to understand how autism and other factors relate to development.

  NIH research Washington University · Saint Louis, United States · NIH-11595423

• DS-ARC: Smartphone-based cognitive check for people with Down syndrome at risk for Alzheimer’s

  A smartphone-based cognitive test is being developed and tested for people with Down syndrome who may develop Alzheimer’s disease, to track changes quietly in daily life.

  NIH research Washington University · Saint Louis, United States · NIH-11588336

• Immune and NGF factors in Alzheimer’s for adults with Down syndrome

  This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.

  NIH research University of California-Irvine · Irvine, United States · NIH-11582785

• Executive Function Support for Young Children with Down Syndrome

  A caregiver-led program helps young children with Down syndrome build executive function skills during a 12-week period.

  NIH research Colorado State University · Fort Collins, United States · NIH-11572720

• SIM2 and mitochondrial health in Down syndrome

  A study tests how a gene linked to Down syndrome affects mitochondria and energy use, with the aim of guiding future therapies for people with Down syndrome and related conditions.

  NIH research Texas A&m Agrilife Research · College Station, UNITED STATES · NIH-11557025

• Down syndrome early childhood omics and deep phenotyping in Texas

  A large study of children with Down syndrome in Texas aims to map their biology and health experiences to improve care and outcomes.

  NIH research Emory University · Atlanta, United States · NIH-11550844

• Infant Down Syndrome Brain and Behavior study

  This project will enroll infants with Down syndrome to collect brain scans, health data, and biosamples to understand early brain development and behavior, with results shared to help families and clinicians in the future.

  NIH research Washington University · Saint Louis, United States · NIH-11545573

• Down Syndrome Connect Registry (DS-Connect) modernized and sustained

  A patient-facing registry project that collects health histories and experiences from individuals with Down syndrome and their families to guide research and better care.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11544980

• ALLY-DS: Improving health and daily life for youth and adults with Down syndrome

  A nationwide effort to study health and well-being in people with Down syndrome across childhood through adulthood, with aims to better understand and support co-occurring conditions.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11541778

• Metabolic Health and Lifestyle in Down Syndrome and Risk of Related Health Conditions

  A nationwide study aims to understand how metabolic health and daily habits affect health conditions like Alzheimer’s-related changes in people with Down syndrome.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11541246

• Remote monitoring of Alzheimer’s changes in adults with Down syndrome

  A study tests remote (at-home) ways to track Alzheimer’s-related thinking changes in adults with Down syndrome.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11532997

• Epigenetic changes in Down syndrome using human cell models

  This grant studies how the epigenetic system in human cells is altered in Down syndrome and how these changes affect brain-related biology.

  NIH research Broad Institute, INC. · Cambridge, United States · NIH-11528961

• Using a JAK inhibitor to help inflammatory skin and scalp problems in people with Down syndrome

  A study tests a JAK-inhibiting medicine to help common skin and scalp conditions in people with Down syndrome.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11526530

• Heterochronic model to understand birth defects in Down syndrome

  A study at the University of Chicago will explore how having an extra chromosome 21 affects heart and brain development, aiming to uncover the causes of common birth defects in Down syndrome.

  NIH research University of Chicago · Chicago, United States · NIH-11516454

• Understanding cell problems in Down syndrome and Down syndrome–associated Alzheimer’s

  This project uses stem cells made from people with Down syndrome and a genetic switch to turn off the extra chromosome so researchers can pinpoint how the extra chromosome causes blood, brain, and Alzheimer‑related changes.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11508915

• How sleep and body temperature affect Alzheimer's risk in adults with Down syndrome

  Researchers will follow adults with Down syndrome over several years to learn whether sleep problems and lower body temperature are linked to earlier Alzheimer's changes.

  NIH research New York University School of Medicine · New York, United States · NIH-11508145

• How speech and swallowing work in people with Down syndrome

  Researchers will look at how differences in the mouth, throat, and brain affect speech clarity and safe swallowing in children and adults with Down syndrome.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11508105

• DS-ARC: A smartphone-based cognitive test for Down syndrome–associated Alzheimer’s disease

  A smartphone-based cognitive test will be developed and tested to help detect early signs of dementia in adults with Down syndrome.

  NIH research Washington University · Saint Louis, United States · NIH-11504766

• DS-ARC: A smartphone-based cognitive test for Down syndrome-associated Alzheimer's disease

  A new smartphone app will measure day-to-day thinking changes in adults with Down syndrome who may develop Alzheimer’s disease, helping catch early signs in a convenient, real-world way.

  NIH research Washington University · Saint Louis, United States · NIH-11504765

• DS-ARC: A Remote Digital Cognitive Test for Down Syndrome-Related Alzheimer’s Disease

  A smartphone-based cognitive test is being developed to help people with Down syndrome who are at risk for Alzheimer’s disease understand and track early brain changes.

  NIH research Washington University · Saint Louis, United States · NIH-11504762

• DS-ARC: A smartphone test to track cognitive change in people with Down syndrome at risk for Alzheimer’s

  A smartphone-based cognitive test is being developed and tested to help monitor early symptoms of Alzheimer’s disease in people with Down syndrome.

  NIH research Washington University · Saint Louis, United States · NIH-11504761

• Understanding why bone heals differently in Down syndrome

  This grant explores why bone healing is slower or abnormal in people with Down syndrome and how to improve it using mouse models.

  NIH research Texas A&m Agrilife Research · College Station, UNITED STATES · NIH-11463437

• Targeting apolipoprotein E4 to slow Alzheimer's in Down syndrome

  This grant aims to find and test ways to block apoE4’s role in Alzheimer’s disease in people with Down syndrome.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11463278

• Brain network problems tied to memory and thinking in adults with Down syndrome

  This project looks at why key brain cells and networks that support memory and self-awareness break down in adults with Down syndrome.

  NIH research St. Joseph's Hospital and Medical Center · Phoenix, United States · NIH-11457058

• Sleep and body temperature changes linked to Alzheimer’s risk in adults with Down syndrome

  This project looks at whether sleep problems and lower body temperature in adults with Down syndrome are linked to higher chances of developing Alzheimer’s disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11456945

• Septohippocampal network problems linking Down syndrome and Alzheimer's disease

  Researchers compare mouse models and human brain cells to understand why people with Down syndrome often develop Alzheimer's disease.

  NIH research New York University School of Medicine · New York, United States · NIH-11456928

• Down Syndrome and Alzheimer’s: Understanding Health Trajectories and Care Using Medicaid Data

  This project uses large health data to understand how Alzheimer’s dementia develops and affects adults with Down syndrome, with the goal of guiding better care and planning.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11449539

• Mobility-powered home play to boost development in infants with Down syndrome

  A home-based program uses a lightweight mobility aid to help infants with Down syndrome move, play, and learn at home.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11448039

• Lifestyle and resilience factors linked to Alzheimer’s in adults with Down syndrome

  A study in adults with Down syndrome looks at how daily lifestyle choices like diet, exercise, body fat, and stress relate to brain changes and memory over time.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11447565

• Understanding why synapses don’t form properly in Down syndrome

  This project looks at why brain connections may be weaker in people with Down syndrome and how this affects learning and behavior.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11447396

• Molecular glue degraders that target APP to help prevent and treat Down syndrome-related dementia

  A new approach aims to use specialized molecules to lower APP protein and reduce brain dementia risk in people with Down syndrome.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11443073

• Understanding how chromosome 21 nondisjunction relates to Down syndrome complications

  Researchers are studying how different errors in chromosome 21 division relate to health issues in children with Down syndrome.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11442677

• Inducible gene dosage correction in Down Syndrome organoid and rodent models carrying human chromosome 21

  A study explores turning down extra chromosome 21 genes in lab-grown brain organoids and animal models to see if it can prevent or lessen Down syndrome–related brain changes.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11442340

• Tracking breathing health in children with Down syndrome using oscillometry

  This grant tests a kid-friendly way to monitor lung health in children with Down syndrome to prevent and better manage respiratory infections.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11430565

• Advance care planning for older adults with Down syndrome and early dementia

  This grant tests how to prepare people with Down syndrome and their caregivers for serious illness and end-of-life care when dementia starts early.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11422946

• Personalized DISE-guided surgery for sleep apnea in children with Down syndrome

  A personalized surgical approach guided by DISE sleep-endoscopy is being tested to better treat sleep apnea in children with Down syndrome who don’t always improve after standard surgery.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11422377

• Enhancing treatments for myeloid leukemia with Down syndrome

  This grant explores how bone marrow support cells affect treatment response in children with Down syndrome–related leukemia and aims to improve chemotherapy effectiveness.

  NIH research Wayne State University · Detroit, United States · NIH-11417888

Related topics

Quick answers

How many Down Syndrome clinical trials are recruiting right now?

48, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (26 trials), Pakistan (11 trials), France (5 trials), Canada (4 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2, Phase 4: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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