Comparing gastric and transpyloric feeding in infants with severe bronchopulmonary dysplasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance, who will be randomized to receive either continuous gastric feeding or continuous transpyloric feeding for two weeks. After this period, the infants will crossover to the alternate feeding method for an additional four weeks. The primary focus is to assess the respiratory status of the infants to determine which feeding mode is optimal for their condition. This crossover design allows for direct comparison within the same subjects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients born \<32 weeks' gestation
* Currently admitted to the Le Bonheur NICU
* Grad 2 or 3 BPD (positive pressure or intubated at 36 weeks PMA)
* Signs of gastroesophageal reflux, chronic aspiration, or other feeding intolerance.

Exclusion Criteria:

* Known gastrointestinal anomalies
* Unable to tolerate ≥100mL/kg/day enteral feeding
* Congenital anomalies likely to alter feeding techniques
* Surgical feeding tube in place or expected within the next 8 weeks
* Expected to remain hospitalized \<8 weeks

Where it's running

• Le Bonheur Children's Hospital
  Memphis, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Mark Weems, MD — University of Tennessee

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using IVIG to treat bronchopulmonary dysplasia in premature infants

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.