Role of Surfactant Protein A and SP-R210 Signaling in Bronchopulmonary Dysplasia
Official title: Role of Surfactant Protein A and Receptor SP-R210 Signaling in Bronchopulmonary Dysplasia.
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11282206 · Data updated 2026-11-12
This NIH grant focuses on how surfactant protein A and its receptor in lung immune cells contribute to bronchopulmonary dysplasia in premature babies.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $178,092 |
| NIH project number | 1K08HL183767-01 |
| Project ID | NIH-11282206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Premature infants at risk for or diagnosed with bronchopulmonary dysplasia, or individuals with early-life lung injury relevant to BPD.
✕Less likely to help
Infants without risk factors for BPD or those not experiencing alveolar injury may not benefit directly.
What this research studies
Bronchopulmonary dysplasia is a serious lung condition in preterm infants. This project investigates how SP-A and SP-R210 influence immune and tissue interactions in the developing lung, especially via alveolar macrophages and extracellular vesicles. The work uses animal models to understand mechanisms that drive injury and impaired alveolar growth, aiming to identify targets to prevent or lessen BPD. By clarifying how intercellular signaling goes awry in BPD, the study could point to new therapeutic strategies for affected infants. The effort builds on prior findings linking SP-A/SP-R210 to lung injury and alveolarization changes.
Why it matters
Potential benefit: A clearer understanding of immune and intercellular signaling pathways could lead to new approaches to prevent or reduce BPD in premature infants.
How similar studies have gone: Previous studies have suggested a role for SP-A and SP-R210 in lung injury, supporting the potential for meaningful insights from this work.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Amatya, Shaili — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Amatya, Shaili
Related research
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This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.