Testing inhaled tobramycin for very preterm infants with lung disease
Phase 1 trial of inhaled tobramycin in very preterm infants with bronchopulmonary dysplasia
This study is looking at how inhaled tobramycin, an antibiotic, can help very preterm babies with bronchopulmonary dysplasia (BPD) by delivering the medicine straight to their lungs to fight harmful bacteria and improve their breathing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10688294 on NIH RePORTER |
What this research studies
This research investigates the use of inhaled tobramycin, an antibiotic, to treat very preterm infants suffering from bronchopulmonary dysplasia (BPD), a serious lung condition. The study aims to deliver the medication directly to the lungs, where it can effectively target harmful bacteria that worsen respiratory health. By focusing on this method, the research seeks to improve outcomes for infants who currently have limited treatment options. The trial will assess the safety and effectiveness of this approach in a vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are very preterm infants diagnosed with bronchopulmonary dysplasia.
Not a fit: Patients who are not very preterm infants or do not have bronchopulmonary dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved respiratory health and quality of life for very preterm infants with bronchopulmonary dysplasia.
How similar studies have performed: Previous research has shown promising results with inhaled antibiotics in similar conditions, suggesting potential for success in this trial.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Downes, Kevin James — Children's Hosp of Philadelphia
- Study coordinator: Downes, Kevin James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.