Testing inhaled tobramycin for very preterm infants with lung disease

Who could benefit from this research

What this research studies

This research investigates the use of inhaled tobramycin, an antibiotic, to treat very preterm infants suffering from bronchopulmonary dysplasia (BPD), a serious lung condition. The study aims to deliver the medication directly to the lungs, where it can effectively target harmful bacteria that worsen respiratory health. By focusing on this method, the research seeks to improve outcomes for infants who currently have limited treatment options. The trial will assess the safety and effectiveness of this approach in a vulnerable population.

Why it matters

Where this research is happening

• Children's Hosp of Philadelphia
  Philadelphia, United States Active

Researchers

• Principal investigator: Downes, Kevin James — Children's Hosp of Philadelphia
• Study coordinator: Downes, Kevin James

Related research

Other NIH-funded projects on the same topics.

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• Screening and treatment of Chlamydia infection in pregnancy to help prevent preterm birth

  This grant studies whether screening pregnant people for Chlamydia trachomatis and treating those who are positive can reduce the risk of preterm birth.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11617691

• Preterm infant body composition and early-life health after NICU stay

  This grant studies how body composition in very preterm babies relates to later brain development and risk of obesity or diabetes, with findings meant to improve care from NICU through early childhood.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11600939

• Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains

  This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11520488

• Xylitol to Prevent Periodontal Disease and Preterm Birth in Pregnancy and Early Childhood

  A safe, inexpensive chewable gum approach using xylitol is tested to help pregnant people reduce gum disease and lower the chance of preterm birth and related child health problems.

  NIH research University of Washington · Seattle, United States · NIH-11478593

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.