Inhaled treatment for chronic lung disease in infants
Pilot Study of an Inhaled Treatment for Bronchopulmonary Dysplasia
This study is looking at how inhaling ethyl nitrite might help improve lung function and oxygen levels in premature babies with bronchopulmonary dysplasia, a serious lung condition, by making their lungs work better.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10455406 on NIH RePORTER |
What this research studies
This research investigates the use of inhaled ethyl nitrite as a treatment for bronchopulmonary dysplasia (BPD), a serious lung condition affecting premature infants. The study aims to improve oxygen levels and reduce respiratory complications by increasing levels of a beneficial compound in the lungs. By administering this treatment, researchers hope to reverse bronchospasm and improve overall lung function in affected infants. The approach is based on previous findings that show promise in animal models and aims to translate these results into clinical practice for newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants diagnosed with bronchopulmonary dysplasia who are experiencing hypoxic respiratory failure.
Not a fit: Patients who are not premature or do not have a diagnosis of bronchopulmonary dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve respiratory health and quality of life for infants suffering from bronchopulmonary dysplasia.
How similar studies have performed: Previous studies have shown success with inhaled treatments for pulmonary conditions, making this approach promising yet still novel for BPD.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Raffay, Thomas Michael — Case Western Reserve University
- Study coordinator: Raffay, Thomas Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.