Role of uneven lung growth in chronic lung disease from birth to adulthood
Official title: The Role of Developmental Dysanapsis in Lung Development Throughout the Lifespan in Experimental Bronchopulmonary Dysplasia
Funded at University of Colorado Denver · NIH-11412719 · Data updated 2026-11-12
This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 9, 2025 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $106,391 |
| NIH project number | 5K38HL180910-02 |
| Project ID | NIH-11412719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; study focuses on developmental biology in a preterm infant model and could inform future patient-centered interventions.
✕Less likely to help
The current work is preclinical and does not enroll patients directly.
What this research studies
If a baby is born very early and develops bronchopulmonary dysplasia (BPD), their lungs may grow in an unbalanced way. The project tests in a model of BPD whether disproportionate airway and tissue growth persists as the child grows and how it shapes lung function, blood vessel health, and vulnerability to lung injuries later in life. By studying biomechanics and structural changes, researchers hope to identify targets to prevent lasting impairment. The work will examine how early inflammatory exposure could set a lifelong trajectory for lung health and resilience to future stressors.
Why it matters
Potential benefit: Understanding the lifelong impact of early lung growth may lead to new strategies to prevent or lessen chronic lung problems in individuals with BPD.
How similar studies have gone: Previous studies show that early dysanaptic growth can occur in BPD models, supporting the plausibility of this approach.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Mcginn, Elizabeth — University of Colorado Denver
- Study coordinator: Mcginn, Elizabeth
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Metabolic clues to BPD-related pulmonary hypertension in babies and teens and adults
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.