Investigating the role of DLL4 in lung development and bronchopulmonary dysplasia in premature infants
DLL4 in the Developing Lung and Bronchopulmonary Dysplasia (BPD)
This study is looking at how a protein called DLL4 impacts lung growth in premature babies, especially those at risk for a serious lung problem called bronchopulmonary dysplasia (BPD), to find ways to help their lungs develop better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11017750 on NIH RePORTER |
What this research studies
This research focuses on understanding how a protein called DLL4 affects lung development in premature infants, particularly in relation to a serious lung condition known as bronchopulmonary dysplasia (BPD). The study examines the molecular mechanisms by which DLL4 influences the formation of blood vessels and air sacs in the lungs. By using mouse models and human cells, researchers aim to uncover how disruptions in DLL4 signaling contribute to BPD and explore potential therapeutic approaches to improve lung health in affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who are at risk of developing bronchopulmonary dysplasia.
Not a fit: Patients who are not premature or do not have lung development issues related to bronchopulmonary dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung development and reduce the incidence of bronchopulmonary dysplasia in premature infants.
How similar studies have performed: Previous research has shown promising results in understanding the role of DLL4 in lung development, suggesting that this approach may lead to significant advancements in treating BPD.
Where this research is happening
Kansas City, United States
- Children's Mercy Hosp (Kansas City, Mo) — Kansas City, United States (Active)
Researchers
- Principal investigator: Sampath, Venkatesh — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Sampath, Venkatesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.