Investigating how IL-33 affects lung injury in premature infants
The role of IL-33 in hyperoxia-induced neonatal lung injury and bronchopulmonary dysplasia
This study is looking at how a protein called IL-33 might be linked to lung problems in premature babies with bronchopulmonary dysplasia (BPD), and the researchers hope to find new ways to help these little ones breathe better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10865078 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein called IL-33 in causing lung injury in premature infants, particularly those who develop a condition known as bronchopulmonary dysplasia (BPD). The research team, led by Dr. Laurie Eldredge at the University of Washington, employs a combination of laboratory experiments and clinical insights to explore how IL-33 influences the immune response in the lungs of neonates. By studying this relationship, the team aims to identify potential therapeutic targets that could improve lung health in affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants who are at risk of developing bronchopulmonary dysplasia.
Not a fit: Patients who are full-term infants or those who do not have respiratory complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung injury and improve outcomes for premature infants.
How similar studies have performed: Previous research has shown promising results in understanding the immune response in neonatal lung injury, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Eldredge, Laurie Christine — University of Washington
- Study coordinator: Eldredge, Laurie Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.