Investigating how IL-33 affects lung injury in premature infants
Official title: The role of IL-33 in hyperoxia-induced neonatal lung injury and bronchopulmonary dysplasia
Funded at University of Washington · NIH-10865078 · Data updated 2026-11-12
This study is looking at how a protein called IL-33 might be linked to lung problems in premature babies with bronchopulmonary dysplasia (BPD), and the researchers hope to find new ways to help these little ones breathe better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $160,056 |
| NIH project number | 5K08HL140104-05 |
| Project ID | NIH-10865078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants who are at risk of developing bronchopulmonary dysplasia.
✕Less likely to help
Patients who are full-term infants or those who do not have respiratory complications may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein called IL-33 in causing lung injury in premature infants, particularly those who develop a condition known as bronchopulmonary dysplasia (BPD). The research team, led by Dr. Laurie Eldredge at the University of Washington, employs a combination of laboratory experiments and clinical insights to explore how IL-33 influences the immune response in the lungs of neonates. By studying this relationship, the team aims to identify potential therapeutic targets that could improve lung health in affected infants.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung injury and improve outcomes for premature infants.
How similar studies have gone: Previous research has shown promising results in understanding the immune response in neonatal lung injury, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Eldredge, Laurie Christine — University of Washington
- Study coordinator: Eldredge, Laurie Christine
Related research
Other NIH-funded projects on the same topics.
-
Role of uneven lung growth in chronic lung disease from birth to adulthood
This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.
-
Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults
This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.
-
Understanding how breathing effort in premature babies with lung disease comes from different lung problems
A research project aims to create a patient-specific tool to measure how different features of bronchopulmonary dysplasia contribute to the struggle to breathe in premature infants.
-
Role of LKB1 in reduced lung blood vessel growth in BPD
Aims to understand how a cellular regulator (LKB1) affects blood vessel formation in the lungs of preterm infants at risk for bronchopulmonary dysplasia.
-
A new approach to prevent bronchopulmonary dysplasia in preterm infants
A new treatment strategy aimed at improving lung development in premature babies at risk for bronchopulmonary dysplasia.
-
L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies
A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.