Understanding breathing difficulties in premature babies with lung disease
Official title: Calculating the Components of Work of Breathing in Neonates with Bronchopulmonary Dysplasia
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10858162 · Data updated 2026-11-12
This study is looking at babies who were born early and have breathing problems called bronchopulmonary dysplasia (BPD), and it aims to create a helpful tool that will figure out how their lungs work so doctors can give them the best care for their specific breathing needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $773,916 |
| NIH project number | 1R01HL173164-01 |
| Project ID | NIH-10858162 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are neonates diagnosed with bronchopulmonary dysplasia, particularly those who were born prematurely.
✕Less likely to help
Patients who do not have bronchopulmonary dysplasia or who are older than 21 years may not benefit from this research.
What this research studies
This research focuses on neonates who have survived premature birth but are affected by bronchopulmonary dysplasia (BPD), a chronic lung condition. The project aims to develop a tool that calculates how different lung characteristics contribute to the effort required for breathing. By identifying specific phenotypes of BPD, the research will help tailor treatments to individual patients based on their unique breathing challenges. This approach seeks to improve the management of breathing difficulties in these vulnerable infants.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for premature infants suffering from bronchopulmonary dysplasia.
How similar studies have gone: While the approach of calculating work of breathing in neonates is innovative, similar methodologies have shown promise in other respiratory conditions, suggesting potential for success.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Bates, Alister — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Bates, Alister
Related research
Other NIH-funded projects on the same topics.
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Role of uneven lung growth in chronic lung disease from birth to adulthood
This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.
-
Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults
This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.
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Understanding how breathing effort in premature babies with lung disease comes from different lung problems
A research project aims to create a patient-specific tool to measure how different features of bronchopulmonary dysplasia contribute to the struggle to breathe in premature infants.
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Role of LKB1 in reduced lung blood vessel growth in BPD
Aims to understand how a cellular regulator (LKB1) affects blood vessel formation in the lungs of preterm infants at risk for bronchopulmonary dysplasia.
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A new approach to prevent bronchopulmonary dysplasia in preterm infants
A new treatment strategy aimed at improving lung development in premature babies at risk for bronchopulmonary dysplasia.
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L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies
A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.