How indoor air quality affects children with lung issues from premature birth
Official title: Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary Dysplasia
Funded at Boston Children's Hospital · NIH-10540413 · Data updated 2026-11-12
This study looks at how the air quality inside homes affects the breathing health of school-aged kids with bronchopulmonary dysplasia, a lung condition from being born early, to find ways to help them breathe better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 15, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $722,583 |
| NIH project number | 5R01ES030100-05 |
| Project ID | NIH-10540413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are school-aged children diagnosed with bronchopulmonary dysplasia.
✕Less likely to help
Patients without a history of bronchopulmonary dysplasia or those who are not school-aged may not benefit from this research.
What this research studies
This research investigates the impact of indoor air quality on respiratory health in school-aged children who have bronchopulmonary dysplasia (BPD), a chronic lung condition often seen in premature infants. The study aims to identify how factors like air pollution and indoor irritants contribute to respiratory symptoms and lung function problems in these children. By analyzing environmental exposures in their homes, the research seeks to uncover potential interventions that could improve their health outcomes. The findings could help guide future strategies to enhance the living conditions for affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved health interventions that reduce respiratory issues in children with bronchopulmonary dysplasia.
How similar studies have gone: Previous research has shown that environmental factors significantly impact respiratory health in children, suggesting that this study's approach is both relevant and necessary.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Gaffin, Jonathan Mark — Boston Children's Hospital
- Study coordinator: Gaffin, Jonathan Mark
Related research
Other NIH-funded projects on the same topics.
-
Role of uneven lung growth in chronic lung disease from birth to adulthood
This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.
-
Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults
This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.
-
Understanding how breathing effort in premature babies with lung disease comes from different lung problems
A research project aims to create a patient-specific tool to measure how different features of bronchopulmonary dysplasia contribute to the struggle to breathe in premature infants.
-
Role of LKB1 in reduced lung blood vessel growth in BPD
Aims to understand how a cellular regulator (LKB1) affects blood vessel formation in the lungs of preterm infants at risk for bronchopulmonary dysplasia.
-
A new approach to prevent bronchopulmonary dysplasia in preterm infants
A new treatment strategy aimed at improving lung development in premature babies at risk for bronchopulmonary dysplasia.
-
L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies
A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.