Understanding lung disease in premature infants through metabolic changes
Official title: Integrative metabolomics of bronchopulmonary dysplasia in extremely low gestational age infants
Funded at University of California, San Francisco · NIH-10808882 · Data updated 2026-11-12
This study is looking at how the metabolism of preterm babies with bronchopulmonary dysplasia (BPD) changes over time by collecting and analyzing their urine and lung fluid, with the goal of finding better ways to care for these little ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2021 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $403,750 |
| NIH project number | 5R01HL153429-04 |
| Project ID | NIH-10808882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are preterm infants at high risk for developing bronchopulmonary dysplasia, particularly those from diverse racial and ethnic backgrounds.
✕Less likely to help
Patients who are not preterm or do not have bronchopulmonary dysplasia may not benefit from this research.
What this research studies
This research investigates bronchopulmonary dysplasia (BPD), a serious lung condition affecting preterm infants, by analyzing changes in their metabolic profiles over time. The study focuses on collecting and examining urine and lung fluid samples from diverse groups of preterm infants to identify how their metabolic changes relate to respiratory health and treatment responses. By understanding these biochemical changes, the research aims to provide insights into the biological mechanisms of BPD and improve care strategies for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic and treatment approaches for bronchopulmonary dysplasia in preterm infants.
How similar studies have gone: Previous research has shown promise in using metabolic profiling to understand various diseases, suggesting that this approach may yield valuable insights for bronchopulmonary dysplasia.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Ballard, Philip L. — University of California, San Francisco
- Study coordinator: Ballard, Philip L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.