Investigating furosemide treatment strategies for severe bronchopulmonary dysplasia in infants
Official title: Furosemide in severe bronchopulmonary dysplasia: comparative effectiveness of a duration and dosage informed treatment strategy
Funded at Children's Hosp of Philadelphia · NIH-10893331 · Data updated 2026-11-12
This study is looking at how different amounts and lengths of a medicine called furosemide can help improve the health of premature babies with a serious lung condition called bronchopulmonary dysplasia (BPD).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 4, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $158,328 |
| NIH project number | 5K23HD101651-05 |
| Project ID | NIH-10893331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants diagnosed with severe bronchopulmonary dysplasia.
✕Less likely to help
Patients who are not premature or do not have a diagnosis of severe bronchopulmonary dysplasia may not benefit from this research.
What this research studies
This research focuses on improving treatment strategies for infants suffering from severe bronchopulmonary dysplasia (BPD), a serious lung condition often seen in premature babies. The study aims to evaluate the effectiveness of different dosages and durations of furosemide, a diuretic medication, to enhance outcomes for these vulnerable patients. By utilizing a patient-oriented approach, the research will gather data on how these treatment strategies impact the health and recovery of infants with severe BPD. The project also emphasizes mentorship and training for the lead investigator to foster future independent research in pediatric care.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment protocols for infants with severe bronchopulmonary dysplasia, potentially improving their long-term health outcomes.
How similar studies have gone: Previous research has shown promising results with similar treatment strategies for bronchopulmonary dysplasia, indicating potential for success in this approach.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Bamat, Nicolas Augusto — Children's Hosp of Philadelphia
- Study coordinator: Bamat, Nicolas Augusto
Related research
Other NIH-funded projects on the same topics.
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Role of uneven lung growth in chronic lung disease from birth to adulthood
This grant explores how mismatched growth of airways, airspaces, and blood vessels during early life might lead to lasting lung problems in bronchopulmonary dysplasia and how that affects people over time.
-
Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults
This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.
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Understanding how breathing effort in premature babies with lung disease comes from different lung problems
A research project aims to create a patient-specific tool to measure how different features of bronchopulmonary dysplasia contribute to the struggle to breathe in premature infants.
-
Role of LKB1 in reduced lung blood vessel growth in BPD
Aims to understand how a cellular regulator (LKB1) affects blood vessel formation in the lungs of preterm infants at risk for bronchopulmonary dysplasia.
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A new approach to prevent bronchopulmonary dysplasia in preterm infants
A new treatment strategy aimed at improving lung development in premature babies at risk for bronchopulmonary dysplasia.
-
L-Citrulline for BPD-related Pulmonary Hypertension in Preterm Babies
A first-in-human study will test safe and effective doses of L-citrulline given by mouth to stability-preterm infants at risk for lung blood pressure problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.