Using MRI to study lung development in infants with Bronchopulmonary Dysplasia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the early development of lungs in infants, particularly focusing on those diagnosed with Bronchopulmonary Dysplasia (BPD). Participants will undergo up to three MRI scans at different stages of their care in the NICU, alongside the collection of urine, blood, and respiratory samples. The study will correlate MRI findings with clinical outcomes and laboratory results to enhance understanding of lung development in premature infants. Additionally, a comparison group of non-BPD NICU patients will be included to gather data on normal lung development.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* any term age NICU patient

Exclusion Criteria:

* \- ECMO,
* Evidence of congenital diseases that may affect lung development, such as congenital diaphragmatic hernia,
* Suspected muscular dystrophy or neurologic disorder that may affect lung development.
* Significant genetic or chromosomal abnormalities that may affect lung development
* Evidence of any respiratory infection at the time of imaging (imaging may be rescheduled for a common viral infection such as a cold).
* Standard MRI exclusion criteria as set forth by the CCHMC Department of Radiology. This includes any contraindications from tracheostomy tubes that are not MR compatible.

Where it's running

• Megan Schmitt
  Cincinnati, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jason Woods, PhD — Children's Hospital Medical Center, Cincinnati
• Study coordinator: Megan Schmitt
• Email: Megan.Schmitt@cchmc.org
• Phone: (513) 636-9348

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using IVIG to treat bronchopulmonary dysplasia in premature infants

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.