How different lung problems add to breathing effort in premature babies with bronchopulmonary dysplasia
Calculating the Components of Work of Breathing in Neonates with Bronchopulmonary Dysplasia
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11169664
This project will build a tool that estimates how much each lung problem makes a premature baby with bronchopulmonary dysplasia work harder to breathe.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11169664 on ClinicalTrials.gov |
What this research studies
If your baby was born very early and has BPD, researchers are developing a tool to figure out which lung changes are making breathing hard. They will measure the parts of breathing effort—stretching the lungs versus pushing air through narrowed airways—and connect those measurements to different BPD patterns like scarring, overinflation, or airway collapse. The team will create calculations that show how much each problem contributes to the baby's work of breathing and test the tool on real infants to confirm it works. That information is meant to help doctors pick treatments that target the specific problem in each baby.
Who could benefit from this research
Good fit: Ideal candidates are premature infants diagnosed with bronchopulmonary dysplasia, particularly those receiving respiratory support or showing mixed lung patterns on imaging or clinical exam.
Not a fit: Babies without BPD, older children or adults, or infants whose lung issues fall outside the studied BPD phenotypes may not benefit from this tool.
Why it matters
Potential benefit: If successful, the tool could help doctors personalize treatments so each baby gets therapies that target the exact lung problem making breathing difficult.
How similar studies have performed: Prior work has described BPD subtypes, but making a validated calculator to quantify each subtype's contribution to breathing effort is a novel and relatively untested approach.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BATES, ALISTER — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: BATES, ALISTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.