Understanding how metabolic processes affect lung disease in premature infants
Official title: Metabolic mechanisms underlying bronchopulmonary dysplasia-associated pulmonary hypertension
Funded at Ocean State Research Institute, INC. · NIH-11092333 · Data updated 2026-11-12
This study is looking at how certain changes in the lungs of premature babies with bronchopulmonary dysplasia can lead to high blood pressure in the lungs, and it hopes to find new ways to help treat or prevent this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ocean State Research Institute, INC. NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $504,803 |
| NIH project number | 5R01HL166327-03 |
| Project ID | NIH-11092333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants diagnosed with moderate to severe bronchopulmonary dysplasia who are at risk of developing pulmonary hypertension.
✕Less likely to help
Patients who are not premature or do not have bronchopulmonary dysplasia may not benefit from this research.
What this research studies
This research investigates the metabolic mechanisms that contribute to pulmonary hypertension in infants with bronchopulmonary dysplasia (BPD). It focuses on how certain cellular processes, particularly the transformation of endothelial cells into smooth muscle cells, lead to changes in the pulmonary blood vessels. By studying these mechanisms in animal models and premature infants, the research aims to identify potential new therapies that could prevent or treat this serious condition. The approach includes analyzing the effects of hyperoxia and mechanical ventilation on lung development and vascular remodeling.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or alleviate pulmonary hypertension in infants with bronchopulmonary dysplasia.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of pulmonary hypertension in similar contexts, suggesting that this approach has potential for success.
Where this research is happening
-
Ocean State Research Institute, INC.
Providence, United States Active
Researchers
- Principal investigator: Yao, Hongwei — Ocean State Research Institute, INC.
- Study coordinator: Yao, Hongwei
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This study is looking for new ways to help premature babies who have bronchopulmonary dysplasia and high blood pressure in their lungs, with the goal of making them healthier and reducing serious health risks.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.